Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/070043
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a heterocyclic compound that potentiates AMPA receptor function and can be expected to be useful as a preventive or therapeutic agent for depression, Alzheimer's disease, schizophrenia, attention deficit hyperactivity disorder (ADHD), and the like. The present invention relates to a compound, or a salt thereof, that is represented by formula (I). (The symbols in the formula are defined in the description.)
Inventors:
NAKAMURA SHINJI (JP)
MIKAMI SATOSHI (JP)
HASUI TOMOAKI (JP)
YAMASHITA TOHRU (JP)
MORIMOTO SHINJI (JP)
TOKUHARA HIDEKAZU (JP)
OYABU NORIO (JP)
YAMADA MASAMI (JP)
OCHIDA ATSUKO (JP)
TAKAMI KAZUAKI (JP)
LIU XIN (CN)
MIKAMI SATOSHI (JP)
HASUI TOMOAKI (JP)
YAMASHITA TOHRU (JP)
MORIMOTO SHINJI (JP)
TOKUHARA HIDEKAZU (JP)
OYABU NORIO (JP)
YAMADA MASAMI (JP)
OCHIDA ATSUKO (JP)
TAKAMI KAZUAKI (JP)
LIU XIN (CN)
Application Number:
PCT/JP2018/037282
Publication Date:
April 11, 2019
Filing Date:
October 04, 2018
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D471/04; A61K31/517; A61K31/519; A61K31/5377; A61K31/538; A61K31/553; A61P25/00; A61P25/28; A61P43/00; C07D519/00; C12N15/09
Domestic Patent References:
| WO2017082288A1 | 2017-05-18 | |||
| WO2016176463A1 | 2016-11-03 | |||
| WO2009119088A1 | 2009-10-01 | |||
| WO2010140339A1 | 2010-12-09 | |||
| WO2011036889A1 | 2011-03-31 | |||
| WO2011036885A1 | 2011-03-31 | |||
| WO2012020848A1 | 2012-02-16 | |||
| WO2012137982A2 | 2012-10-11 | |||
| WO2013118845A1 | 2013-08-15 |
Foreign References:
| JP2011525909A | 2011-09-29 | |||
| JP2009516676A | 2009-04-23 | |||
| JP2017195904A | 2017-11-02 |
Other References:
YAN, JIN-WU ET AL.: "Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, no. 8, 2012, pages 2527 - 2534, XP055590646
PHARMACOLOGICAL REVIEWS, vol. 51, 1999, pages 7 - 61
NEUROPHARMACOLOGY, vol. 34, 1995, pages 123 - 139
ANNUAL REVIEW OF NEUROSCIENCE, vol. 25, 2002, pages 103 - 126
CNS NEUROLOGICAL DISORDERS-DRUG TARGETS, vol. 7, 2008, pages 129 - 143
CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, vol. 9, 2006, pages 571 - 579
JOURNAL OF NEUROSCIENCE, vol. 27, 2007, pages 10912 - 10917
NEUROBIOLOGY OF DISEASE, vol. 47, 2012, pages 210 - 215
JOURNAL OF NEUROSCIENCE, vol. 31, 2011, pages 3766 - 3775
JOURNAL OF NEUROPHYSIOLOGY, vol. 94, 2005, pages 1814 - 1824
L. F. TIETZETH. EICHER: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. I-VII, 1989, JOHN WILEY & SONS INC
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
See also references of EP 3693368A4
PHARMACOLOGICAL REVIEWS, vol. 51, 1999, pages 7 - 61
NEUROPHARMACOLOGY, vol. 34, 1995, pages 123 - 139
ANNUAL REVIEW OF NEUROSCIENCE, vol. 25, 2002, pages 103 - 126
CNS NEUROLOGICAL DISORDERS-DRUG TARGETS, vol. 7, 2008, pages 129 - 143
CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, vol. 9, 2006, pages 571 - 579
JOURNAL OF NEUROSCIENCE, vol. 27, 2007, pages 10912 - 10917
NEUROBIOLOGY OF DISEASE, vol. 47, 2012, pages 210 - 215
JOURNAL OF NEUROSCIENCE, vol. 31, 2011, pages 3766 - 3775
JOURNAL OF NEUROPHYSIOLOGY, vol. 94, 2005, pages 1814 - 1824
L. F. TIETZETH. EICHER: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. I-VII, 1989, JOHN WILEY & SONS INC
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
See also references of EP 3693368A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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