Title:
HETEROCYCLIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2019/070044
Kind Code:
A1
Abstract:
A purpose of the present invention is to provide a heterocyclic compound that has an AMPA receptor function enhancing action, and can be expected to be useful as a prevention or treatment for depression, Alzheimer's disease, schizophrenia, attention-deficit hyperactivity disorder (ADHD), or similar. The present invention relates to compounds expressed by formula (I) [wherein each symbol is as defined in the specification], or salts thereof.
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Inventors:
HASUI TOMOAKI (JP)
NAKAMURA SHINJI (JP)
MIKAMI SATOSHI (JP)
YAMASHITA TOHRU (JP)
NAKAMURA SHINJI (JP)
MIKAMI SATOSHI (JP)
YAMASHITA TOHRU (JP)
Application Number:
PCT/JP2018/037283
Publication Date:
April 11, 2019
Filing Date:
October 04, 2018
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D235/10; A61K31/4184; A61K31/437; A61K31/5377; A61K31/553; A61P25/00; A61P25/28; A61P43/00; C07D407/12; C07D413/10; C07D471/04; C12N15/09
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Other References:
WALL, MICHAEL D. ET AL.: "Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4, 5, 6, 7-tetrahydro-1H-i midazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 10, 2007, pages 2740 - 2744, XP022049579, DOI: doi:10.1016/j.bmcl.2007.02.078
PHARMACOLOGICAL REVIEWS, vol. 51, 1999, pages 7 - 61
NEUROPHARMACOLOGY, vol. 34, 1995, pages 123 - 139
ANNUAL REVIEW OF NEUROSCIENCE, vol. 25, 2002, pages 103 - 126
CNS NEUROLOGICAL DISORDERS-DRUG TARGETS, vol. 7, 2008, pages 129 - 143
CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, vol. 9, 2006, pages 571 - 579
JOURNAL OF NEUROSCIENCE, vol. 27, 2007, pages 10912 - 10917
NEUROBIOLOGY OF DISEASE, vol. 47, 2012, pages 210 - 215
JOURNAL OF NEUROSCIENCE, vol. 31, 2011, pages 3766 - 3775
JOURNAL OF NEUROPHYSIOLOGY, vol. 94, 2005, pages 1814 - 1824
BIOORGANIC MEDICINAL CHEMISTRY, vol. 23, no. 13, pages 3351 - 67
"Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. I-VII, 1989, CHEMICAL SOCIETY OF JAPAN
"Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
"Protecting Groups", 2004, THIEME
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
See also references of EP 3693360A4
PHARMACOLOGICAL REVIEWS, vol. 51, 1999, pages 7 - 61
NEUROPHARMACOLOGY, vol. 34, 1995, pages 123 - 139
ANNUAL REVIEW OF NEUROSCIENCE, vol. 25, 2002, pages 103 - 126
CNS NEUROLOGICAL DISORDERS-DRUG TARGETS, vol. 7, 2008, pages 129 - 143
CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, vol. 9, 2006, pages 571 - 579
JOURNAL OF NEUROSCIENCE, vol. 27, 2007, pages 10912 - 10917
NEUROBIOLOGY OF DISEASE, vol. 47, 2012, pages 210 - 215
JOURNAL OF NEUROSCIENCE, vol. 31, 2011, pages 3766 - 3775
JOURNAL OF NEUROPHYSIOLOGY, vol. 94, 2005, pages 1814 - 1824
BIOORGANIC MEDICINAL CHEMISTRY, vol. 23, no. 13, pages 3351 - 67
"Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. I-VII, 1989, CHEMICAL SOCIETY OF JAPAN
"Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
"Protecting Groups", 2004, THIEME
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
See also references of EP 3693360A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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