Title:
HIGH MOLECULAR MICELLES INCLUDING NOVEL BLOCK COPOLYMER
Document Type and Number:
WIPO Patent Application WO/2023/149528
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a drug delivery system for efficient delivery of a drug to the brain. The present invention provides high molecular micelles comprising: a first block copolymer that is composed of a hydrophilic polymer segment and a cationic polyamino acid segment and that can bind to a drug; and a second block copolymer that is composed of a hydrophilic polymer segment and a cationic polyamino acid segment and that can bind to a ligand that binds to a target. The cationic polyamino acid segment of the first block copolymer is a polyamino acid segment comprising: leucine; and a cationic amino acid selected from the group consisting of lysine, ornithine, arginine, homoarginine, histidine, and Asp(DET).
Inventors:
NAGASAKI TOMOHIRO (JP)
SAITO HIROYUKI (JP)
SAITO HIROYUKI (JP)
Application Number:
PCT/JP2023/003503
Publication Date:
August 10, 2023
Filing Date:
February 03, 2023
Export Citation:
Assignee:
BRAIZON THERAPEUTICS INC (JP)
International Classes:
A61K47/59; A61K9/10; A61K31/7105; A61K31/711; A61K38/00; A61K47/60; A61P25/00
Other References:
"Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications", vol. 1271, 1 January 2017, AMERICAN CHEMICAL SOCIETY, Washington, DC, ISBN: 978-0-8412-3273-0, ISSN: 0097-6156, article BAILEY CHRISTINA M., NAGARAJAN RAMANATHAN, CAMESANO TERRI A.: "Designing Polymer Micelles of Controlled Size, Stability, and Functionality for siRNA Delivery", pages: 35 - 70, XP093082490, DOI: 10.1021/bk-2017-1271.ch002
DENG JIZHE, GAO NINGNING, WANG YANAN, YI HUQIANG, FANG SHENGTAO, MA YIFAN, CAI LINTAO: "Self-Assembled Cationic Micelles Based on PEG-PLL-PLLeu Hybrid Polypeptides as Highly Effective Gene Vectors", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 11, 12 November 2012 (2012-11-12), US , pages 3795 - 3804, XP093057271, ISSN: 1525-7797, DOI: 10.1021/bm3012538
LUO ZICHAO, WANG CE, YI HUQIANG, LI PING, PAN HONG, LIU LANLAN, CAI LINTAO, MA YIFAN: "Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 38, 1 January 2015 (2015-01-01), AMSTERDAM, NL , pages 50 - 60, XP093082493, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2014.10.050
WEI GUOQING, WANG YI, HUANG XUEHUI, HOU HUABO, ZHOU SHAOBING: "Peptide‐Based Nanocarriers for Cancer Therapy", SMALL METHODS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 2, no. 9, 1 September 2018 (2018-09-01), DE , XP093082494, ISSN: 2366-9608, DOI: 10.1002/smtd.201700358
MIYAMOTO TAKAAKI, TSUCHIYA KOUSUKE, NUMATA KEIJI: "Block Copolymer/Plasmid DNA Micelles Postmodified with Functional Peptides via Thiol–Maleimide Conjugation for Efficient Gene Delivery into Plants", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 20, no. 2, 11 February 2019 (2019-02-11), US , pages 653 - 661, XP093082497, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01304
DENG JIZHE, GAO NINGNING, WANG YANAN, YI HUQIANG, FANG SHENGTAO, MA YIFAN, CAI LINTAO: "Self-Assembled Cationic Micelles Based on PEG-PLL-PLLeu Hybrid Polypeptides as Highly Effective Gene Vectors", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 11, 12 November 2012 (2012-11-12), US , pages 3795 - 3804, XP093057271, ISSN: 1525-7797, DOI: 10.1021/bm3012538
LUO ZICHAO, WANG CE, YI HUQIANG, LI PING, PAN HONG, LIU LANLAN, CAI LINTAO, MA YIFAN: "Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 38, 1 January 2015 (2015-01-01), AMSTERDAM, NL , pages 50 - 60, XP093082493, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2014.10.050
WEI GUOQING, WANG YI, HUANG XUEHUI, HOU HUABO, ZHOU SHAOBING: "Peptide‐Based Nanocarriers for Cancer Therapy", SMALL METHODS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 2, no. 9, 1 September 2018 (2018-09-01), DE , XP093082494, ISSN: 2366-9608, DOI: 10.1002/smtd.201700358
MIYAMOTO TAKAAKI, TSUCHIYA KOUSUKE, NUMATA KEIJI: "Block Copolymer/Plasmid DNA Micelles Postmodified with Functional Peptides via Thiol–Maleimide Conjugation for Efficient Gene Delivery into Plants", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 20, no. 2, 11 February 2019 (2019-02-11), US , pages 653 - 661, XP093082497, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01304
Attorney, Agent or Firm:
OSAWA Kenichi (JP)
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