Title:
HIGH THROUGHPUT ASSAY TO DETECT INHIBITORS OF THE MAP KINASE PATHWAY
Document Type and Number:
WIPO Patent Application WO2002047535
Kind Code:
A3
Abstract:
The present invention provides an assay for screening modulators of the MAPK pathway that are useful for the treatment of cancers. In addition, the present invention provides reagents and methods for detecting modulators of the MAPK pathway.
Inventors:
YAMAMOTO HIROTAKA (US)
MOSKAL JOSEPH (US)
MOSKAL JOSEPH (US)
Application Number:
PCT/US2001/047766
Publication Date:
January 23, 2003
Filing Date:
December 14, 2001
Export Citation:
Assignee:
NYXIS NEUROTHERAPIES INC (US)
YAMAMOTO HIROTAKA (US)
MOSKAL JOSEPH (US)
YAMAMOTO HIROTAKA (US)
MOSKAL JOSEPH (US)
International Classes:
C12Q1/68; C12Q1/6886; C12Q1/6897; (IPC1-7): C12Q1/68; G01N33/53; C12N1/20; C12N15/85
Other References:
WATTERS ET AL.: "Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signaling cascade and c-fos immediate early gene transcription", ENDOCRINOLOGY, vol. 138, no. 9, 1997, pages 4030 - 4033, XP002956818
STEPAN ET AL.: "Cell type-specific requirement of the MAKP pathway for the growth factor action of gastrin", AMER. J. PHYSIOL., vol. 276, no. 6, PT. 1, 1999, pages G1363 - G1372, XP002956817
ROBERSON ET AL.: "Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone", ENDOCRINOLOGY, vol. 140, no. 3, 1999, pages 1310 - 1318, XP002956816
SANTIBANEZ ET AL.: "Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta 1 in transformed keratinocytes", BIOCHEM. BIOPHYS. RES. COMM., vol. 273, 2000, pages 521 - 527, XP002956815
STEPAN ET AL.: "Cell type-specific requirement of the MAKP pathway for the growth factor action of gastrin", AMER. J. PHYSIOL., vol. 276, no. 6, PT. 1, 1999, pages G1363 - G1372, XP002956817
ROBERSON ET AL.: "Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone", ENDOCRINOLOGY, vol. 140, no. 3, 1999, pages 1310 - 1318, XP002956816
SANTIBANEZ ET AL.: "Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta 1 in transformed keratinocytes", BIOCHEM. BIOPHYS. RES. COMM., vol. 273, 2000, pages 521 - 527, XP002956815
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