Title:
HIGHLY FUNCTIONALIZED STEM CELL/PROGENITOR CELL BY APE1 GENE TRANSFECTION
Document Type and Number:
WIPO Patent Application WO/2012/020566
Kind Code:
A1
Abstract:
The present invention relates to highly functionalized stem cells/progenitor cells, such as vascular endothelial progenitor cells and mesenchymal stem cells having improved functions such as angiogenesis by enhanced Ape1 expression, and a revascularization treatment method using same.
Inventors:
KAWABE JUNICHI (JP)
YAMAUCHI ATSUSHI (JP)
TAKEHARA YUJI (JP)
HASEBE NAOYUKI (JP)
YAMAUCHI ATSUSHI (JP)
TAKEHARA YUJI (JP)
HASEBE NAOYUKI (JP)
Application Number:
PCT/JP2011/004508
Publication Date:
February 16, 2012
Filing Date:
August 09, 2011
Export Citation:
Assignee:
NAT UNIVERSITY CORP ASAHIKAWA MEDICAL UNIVERSITY (JP)
KAWABE JUNICHI (JP)
YAMAUCHI ATSUSHI (JP)
TAKEHARA YUJI (JP)
HASEBE NAOYUKI (JP)
KAWABE JUNICHI (JP)
YAMAUCHI ATSUSHI (JP)
TAKEHARA YUJI (JP)
HASEBE NAOYUKI (JP)
International Classes:
C12N5/10; A61K9/70; A61K35/28; A61K35/34; A61K35/44; A61P9/10; A61P35/00; C12N5/07; C12N15/09
Domestic Patent References:
| WO2008142862A1 | 2008-11-27 | |||
| WO2008142862A1 | 2008-11-27 |
Foreign References:
| JP2009189743A | 2009-08-27 | |||
| JP2007089536A | 2007-04-12 | |||
| JP2010179605A | 2010-08-19 | |||
| JP2003250820A | 2003-09-09 | |||
| JP2005287418A | 2005-10-20 | |||
| JP2005110565A | 2005-04-28 | |||
| US4202875A | 1980-05-13 |
Other References:
HEO J Y ET AL.: "Downregulation of APE1/Ref-1 is involved in the Senescence of Mesencymal Stem Cells", STEM CELLS, vol. 27, no. 6, 2009, pages 1455 - 1462, XP003031463
CHENG C ET AL.: "Protective effect of simvastatin on inflammatory injury of EPCs", JIANGSU MED J., vol. 35, no. 2, 2009, pages 205 - 207, XP008165908
MOHRI T ET AL.: "Signals Through Glycoprotein 130 Regulate the Endothelial Differentiation of Cardiac Stem Cells", ARTERIOSCLER THROMB VASC BIOL., vol. 29, 2009, pages 754 - 760, XP055070608
ZOU GM ET AL.: "The Ape-l/Ref-1 Redox Antagonist E3330 Inhibits the Growth of Tumor Endothelium and Endothelial Progenitor Cells: Therapeutic Implications in Tumor Angiogenesis", J CELL PHYSIOL., vol. 219, 2009, pages 209 - 218, XP055070637
ZHANG Y ET AL.: "Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-a via the p38 mitogen-activated protein kinase pathway", FASEB J., vol. 23, 2009, pages 1358 - 1365, XP005070640
HENRICH D ET AL.: "High Dosage of Simvastatin Reduces TNF-a-induced apoptosis of Endothelial Progenitor Cells but Fails to Prevent Apoptosis Induced by IL-lp In Vitro", J SURG RES., vol. 142, no. 1, 2007, pages 13 - 19, XP022208394
SCIENCE, vol. 275, 1997, pages 964 - 967
NEW ENG J MED, vol. 348, 2003, pages 593 - 600
NEW ENG J MED, vol. 353, 2005, pages 999 - 1007
LANCET, vol. 360, 2002, pages 427 - 435
CIRCULATION, vol. 106, 2002, pages 2781 - 2786
ARTERIO THROMB VASC BIOL, 2006, pages 2140 - 2146
DIABETES, vol. 56, 2007, pages 1559 - 1568
JOURNAL OF CELLULAR PHYSIOLOGY, 2008, pages 209 - 218
BIOCHEMICAL AND BIOPHYSICAL COMMUNICATIONS, vol. 368, 2008, pages 68 - 73
MIYAKE, S. ET AL., PROC. NATL. ACAD. SCI., vol. 93, 1993, pages 1320 - 1324
KANEGAE Y., NUCL. ACIDS RES., vol. 23, 1995, pages 3816
GREEN; LOEWENSTEIN, CELL, vol. 56, no. 6, 1988, pages 1179 - 88
FRANKEL; PABO, CELL, vol. 55, no. 6, 1988, pages 1189 - 93
VIVES ET AL., J. BIOL. CHEM, vol. 272, no. 25, 1997, pages 16010 - 7
ELLIOTT; O'HARE, CELL, vol. 88, no. 2, 1997, pages 223 - 33
CHOMCZYNSKI, P.; SACCHI, N., ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
MEAGER A., CLIN EXP IMMUNOL., vol. 2, no. 1, 13 April 2003 (2003-04-13), pages 128 - 36
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
"Monoclonal Antibodies", 1980, PLENUM PRESS, pages: 365 - 367
See also references of EP 2604686A4
CHENG C ET AL.: "Protective effect of simvastatin on inflammatory injury of EPCs", JIANGSU MED J., vol. 35, no. 2, 2009, pages 205 - 207, XP008165908
MOHRI T ET AL.: "Signals Through Glycoprotein 130 Regulate the Endothelial Differentiation of Cardiac Stem Cells", ARTERIOSCLER THROMB VASC BIOL., vol. 29, 2009, pages 754 - 760, XP055070608
ZOU GM ET AL.: "The Ape-l/Ref-1 Redox Antagonist E3330 Inhibits the Growth of Tumor Endothelium and Endothelial Progenitor Cells: Therapeutic Implications in Tumor Angiogenesis", J CELL PHYSIOL., vol. 219, 2009, pages 209 - 218, XP055070637
ZHANG Y ET AL.: "Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-a via the p38 mitogen-activated protein kinase pathway", FASEB J., vol. 23, 2009, pages 1358 - 1365, XP005070640
HENRICH D ET AL.: "High Dosage of Simvastatin Reduces TNF-a-induced apoptosis of Endothelial Progenitor Cells but Fails to Prevent Apoptosis Induced by IL-lp In Vitro", J SURG RES., vol. 142, no. 1, 2007, pages 13 - 19, XP022208394
SCIENCE, vol. 275, 1997, pages 964 - 967
NEW ENG J MED, vol. 348, 2003, pages 593 - 600
NEW ENG J MED, vol. 353, 2005, pages 999 - 1007
LANCET, vol. 360, 2002, pages 427 - 435
CIRCULATION, vol. 106, 2002, pages 2781 - 2786
ARTERIO THROMB VASC BIOL, 2006, pages 2140 - 2146
DIABETES, vol. 56, 2007, pages 1559 - 1568
JOURNAL OF CELLULAR PHYSIOLOGY, 2008, pages 209 - 218
BIOCHEMICAL AND BIOPHYSICAL COMMUNICATIONS, vol. 368, 2008, pages 68 - 73
MIYAKE, S. ET AL., PROC. NATL. ACAD. SCI., vol. 93, 1993, pages 1320 - 1324
KANEGAE Y., NUCL. ACIDS RES., vol. 23, 1995, pages 3816
GREEN; LOEWENSTEIN, CELL, vol. 56, no. 6, 1988, pages 1179 - 88
FRANKEL; PABO, CELL, vol. 55, no. 6, 1988, pages 1189 - 93
VIVES ET AL., J. BIOL. CHEM, vol. 272, no. 25, 1997, pages 16010 - 7
ELLIOTT; O'HARE, CELL, vol. 88, no. 2, 1997, pages 223 - 33
CHOMCZYNSKI, P.; SACCHI, N., ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
MEAGER A., CLIN EXP IMMUNOL., vol. 2, no. 1, 13 April 2003 (2003-04-13), pages 128 - 36
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
"Monoclonal Antibodies", 1980, PLENUM PRESS, pages: 365 - 367
See also references of EP 2604686A4
Attorney, Agent or Firm:
OHNO, Seiji et al. (JP)
Seiji Ono (JP)
Seiji Ono (JP)
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Claims: