Title:
HISTONE DEACETYLASE INHIBITOR HAVING NITROGEN-CONTAINING AROMATIC HETEROCYCLIC GROUP
Document Type and Number:
WIPO Patent Application WO/2021/117759
Kind Code:
A1
Abstract:
Provided is a novel compound having an HDAC2-inhibitory effect. The present invention is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. (In the formula, the group represented by formula (II) is formula (III), or the like (in the formula, each R3 is independently an amino or the like, and n is an integer between 0 and 4), where X1 is N or the like, X2 is N or the like, R4 and R5 are each independently a hydrogen atom or the like, R1 is a nonaromatic carbocyclic group or the like optionally substituted by a substitution group selected from category C, substitution group category C includes halogens, and R 2 is a hydrogen atom).
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Inventors:
ANAN KOSUKE (JP)
YAMAKAWA HIDEKUNI (JP)
YOSHIHARA KEN (JP)
NAKAHARA KENJI (JP)
TAKAYA KENJI (JP)
MIZOTE KEISUKE (JP)
KAI HIROYUKI (JP)
YAMAKAWA HIDEKUNI (JP)
YOSHIHARA KEN (JP)
NAKAHARA KENJI (JP)
TAKAYA KENJI (JP)
MIZOTE KEISUKE (JP)
KAI HIROYUKI (JP)
Application Number:
PCT/JP2020/045829
Publication Date:
June 17, 2021
Filing Date:
December 09, 2020
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D401/04; A61K31/422; A61K31/427; A61K31/435; A61K31/4353; A61K31/4355; A61K31/436; A61K31/437; A61K31/4375; A61K31/4439; A61K31/4709; A61K31/497; A61K31/498; A61K31/4985; A61K31/501; A61K31/5025; A61K31/506; A61K31/519; A61K31/5377; A61K31/5383; A61P43/00; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/14; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D487/04; C07D491/052; C07D491/056; C07D498/04
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See also references of EP 4074700A4
THE JOURNAL OF NEUROSCIENCE, vol. 33, no. 14, 2013, pages 5924 - 5929
NATURE, vol. 483, no. 7388, 2012, pages 222 - 226
NATURE, vol. 459, no. 7243, 2009, pages 55 - 60
NATURE NEUROSCIENCE, vol. 15, no. 9, 2012, pages 1245 - 1254
THE EMBO JOURNAL, vol. 29, no. 15, 2010, pages 2586 - 2597
CHEMICAL SCIENCE, vol. 6, 2015, pages 804 - 815
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 2010, pages 3142 - 3145
6TH CSJ CHEMISTRY FESTA 2016 PROCEEDINGS CHALLENGE INTRACTABLE DISEASES WITH THE POWER OF CHEMISTRY -EPIGENETICS MEDICINAL CHEMISTRY
CELL REPORTS, vol. 22, no. 13, 2018, pages 3393 - 3400
"Isotopes in the Physical and Biomedical Sciences", vol. 1, 1987, article "Labeled Compounds"
"Design of Prodrugs", 1985, ELSEVIER
JOURNAL OF PESTICIDE SCIENCE, vol. 25, 2000, pages 24 - 30
See also references of EP 4074700A4
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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