Title:
HMGB1 EXPRESSION SUPPRESSOR, PROPHYLACTIC OR THERAPEUTIC DRUG FOR ACUTE LUNG INJURY, ACUTE RESPIRATORY DISTRESS SYNDROME OR SEPSIS, AND METHOD FOR AMELIORATING SUCH DISEASE
Document Type and Number:
WIPO Patent Application WO/2023/248844
Kind Code:
A1
Abstract:
Provided are: an HMGB1 expression suppressor comprising a microparticle, in which the microparticle contains miRNA of which the target gene is a gene associated with the expression of HMGB1, the HMGB1 expression suppressor being a novel HMGB1 expression suppressor capable of controlling the expression of HMGB1 by utilizing miRNA derived from the microparticle; a prophylactic or therapeutic drug for acute lung injury, acute respiratory distress syndrome or sepsis; and a method for ameliorating acute lung injury, acute respiratory distress syndrome or sepsis. The microparticle is preferably an exosome.
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Inventors:
KOGA SHOJI (JP)
Application Number:
PCT/JP2023/021640
Publication Date:
December 28, 2023
Filing Date:
June 12, 2023
Export Citation:
Assignee:
DEXON PHARMACEUTICALS INC (JP)
International Classes:
A61K35/32; A61K9/14; A61K31/7105; A61K35/28; A61K47/46; A61K48/00; A61P9/00; A61P9/08; A61P9/10; A61P11/00; A61P29/00; A61P31/04; A61P37/06; A61P43/00
Domestic Patent References:
| WO2021153719A1 | 2021-08-05 |
Foreign References:
| JP2022045297A | 2022-03-18 | |||
| CN113398150A | 2021-09-17 |
Other References:
HUANG XIANGYU, QIU WEI, PAN YUHUA, LI JIANJIA, CHEN ZHAO, ZHANG KAIYING, LUO YIFEI, WU BULING, XU WENAN: "Exosomes from LPS-Stimulated hDPSCs Activated the Angiogenic Potential of HUVECs In Vitro", STEM CELLS INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, US, vol. 2021, 15 April 2021 (2021-04-15), US , pages 1 - 15, XP093119947, ISSN: 1687-966X, DOI: 10.1155/2021/6685307
NAKATSUKA, R. et al. PARP1 regulates cellular processes mediated by exosomal miRNAs in dental pulp stem cells. Journal of Hard Tissue Biology. 2021, vol. 30, no. 4, pp. 371-378
NAKATSUKA, R. et al. PARP1 regulates cellular processes mediated by exosomal miRNAs in dental pulp stem cells. Journal of Hard Tissue Biology. 2021, vol. 30, no. 4, pp. 371-378
Attorney, Agent or Firm:
SUGAWARA Tetsuro (JP)
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