Title:
PTX3 EXPRESSION CONTROL AGENT, PROPHYLACTIC DRUG OR THERAPEUTIC DRUG FOR VASCULITIS OR HARDENING OF SKIN ASSOCIATED WITH RHEUMATOID ARTHRITIS, AUTOIMMUNE DISEASE, METHOD FOR IMPROVING VASCULITIS OR HARDENING OF SKIN ASSOCIATED WITH RHEUMATOID ARTHRITIS, AUTOIMMUNE DISEASE
Document Type and Number:
WIPO Patent Application WO/2023/248845
Kind Code:
A1
Abstract:
The present invention provides: a novel PTX3 expression control agent that uses miRNA from fine particles to control PTX3 expression, the PTX3 expression control agent including fine particles that include miRNA that targets a gene related to PTX3 expression; a prophylactic drug or therapeutic drug for vasculitis or hardening of the skin associated with rheumatoid arthritis, autoimmune disease; a method for improving vasculitis or hardening of the skin associated with rheumatoid arthritis, autoimmune disease. The fine particles are preferably exosomes.
Inventors:
KOGA SHOJI (JP)
Application Number:
PCT/JP2023/021641
Publication Date:
December 28, 2023
Filing Date:
June 12, 2023
Export Citation:
Assignee:
DEXON PHARMACEUTICALS INC (JP)
International Classes:
A61K35/32; A61K9/14; A61K31/7105; A61K35/28; A61K47/46; A61K48/00; A61P9/00; A61P9/08; A61P9/10; A61P17/00; A61P19/02; A61P29/00; A61P37/02; A61P37/06; A61P43/00; C12N15/113
Domestic Patent References:
| WO2014126176A1 | 2014-08-21 |
Foreign References:
| US20150342998A1 | 2015-12-03 | |||
| CN115501252A | 2022-12-23 |
Other References:
JI LUJUN; BAO LIULIU; GU ZHIFENG; ZHOU QIAO; LIANG YI; ZHENG YA; XU YANG; ZHANG XIANG; FENG XINGMEI: "Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells", IMMUNOLOGY RESEARCH, HUMANA PRESS, INC, US, vol. 67, no. 4-5, 13 August 2019 (2019-08-13), US , pages 432 - 442, XP036957213, ISSN: 0257-277X, DOI: 10.1007/s12026-019-09088-6
NAKATSUKA RYUSUKE, SASAKI YUKA, MASUTANI MITSUKO, NOZAKI TADASHIGE: "PARP1 Regulates Cellular Processes Mediated by Exosomal miRNAs in Dental Pulp Stem Cells", JOURNAL OF HARD TISSUE BIOLOGY, vol. 30, no. 4, 1 January 2021 (2021-01-01), pages 371 - 378, XP093119949, ISSN: 1341-7649, DOI: 10.2485/jhtb.30.371
NAKATSUKA RYUSUKE, SASAKI YUKA, MASUTANI MITSUKO, NOZAKI TADASHIGE: "PARP1 Regulates Cellular Processes Mediated by Exosomal miRNAs in Dental Pulp Stem Cells", JOURNAL OF HARD TISSUE BIOLOGY, vol. 30, no. 4, 1 January 2021 (2021-01-01), pages 371 - 378, XP093119949, ISSN: 1341-7649, DOI: 10.2485/jhtb.30.371
Attorney, Agent or Firm:
SUGAWARA Tetsuro (JP)
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