Title:
HPLC ANALYSIS METHOD FOR N- (PHENYLSULFONYL) BENZAMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/227763
Kind Code:
A1
Abstract:
Provided is an HPLC analysis method of N-(phenylsulfonyl)benzamide compound; the N-(phenylsulfonyl)benzamide compound is substance X; the substance X is a compound as represented by formula I-A and/or I-B. The HPLC analysis method comprises the following steps: eluting substance X with a mobile phase comprising an alkane solvent, an alcohol solvent, a halogenated hydrocarbon solvent and an ether solvent, in parts by volume, the alkane solvent is 600-800 parts, the alcohol solvent is 50-350 parts, the halogenated hydrocarbon solvents is 30-100 parts, and the ether solvents is 50-200 parts. The analysis method can separate isomers and precisely determine the purity of the isomers.
Inventors:
ZHANG XIANXIN (CN)
NI YOUFENG (CN)
SUN ZHIPENG (CN)
CHEN MINGYUAN (CN)
ZHANG XIAONI (CN)
NI YOUFENG (CN)
SUN ZHIPENG (CN)
CHEN MINGYUAN (CN)
ZHANG XIAONI (CN)
Application Number:
PCT/CN2021/087406
Publication Date:
November 18, 2021
Filing Date:
April 15, 2021
Export Citation:
Assignee:
ASCENTAGE PHARMA SUZHOU CO LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
International Classes:
G01N30/02
Domestic Patent References:
| WO2018027097A1 | 2018-02-08 |
Foreign References:
| CN111537654A | 2020-08-14 |
Other References:
SUN TING-TING;SU DAN;CHEN JING;ZHAO LONG-SHAN;GUO XING-JIE: "Enantioseparation of six racemic β-blockers byhigh performance liquid chromatographyon immobilized cellulose chiral stationary phase", JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY, vol. 33, no. 3, 20 March 2016 (2016-03-20), pages 220 - 225, XP055866255, ISSN: 1006-2858, DOI: 10.14066/j.cnki.cn21-1349/r.2016.03.008
WEN XIAOLI;SHI XINRU;HAI QINGMEI;ZHOU BINGJIE;LIU YANG;GUO XINGJIE: "Enantioseparation of four basic drugs by Chiralpak IC column", JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY, vol. 35, no. 7, 20 July 2018 (2018-07-20), pages 563 - 567, XP055866252, ISSN: 1006-2858, DOI: 10.14066/j.cnki.cn21-1349/r.2018.07.009
WEN XIAOLI;SHI XINRU;HAI QINGMEI;ZHOU BINGJIE;LIU YANG;GUO XINGJIE: "Enantioseparation of four basic drugs by Chiralpak IC column", JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY, vol. 35, no. 7, 20 July 2018 (2018-07-20), pages 563 - 567, XP055866252, ISSN: 1006-2858, DOI: 10.14066/j.cnki.cn21-1349/r.2018.07.009
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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