Title:
HUMAN MEGALIN DETERMINATION METHOD
Document Type and Number:
WIPO Patent Application WO/2007/119563
Kind Code:
A1
Abstract:
The object is to provide: a human megalin determination method which is simpler and can be achieved within a shorter time compared to a conventional method, and can also determine human megalin quantitatively; and a diagnosis method which can diagnose a cell-, tissue- or organ-specific functional disease directly in an affected site at an early stage of the disease. Disclosed is a method for detection of an organ disease in which the expression of megalin is characteristically observed, by means of determining human megalin.
Inventors:
OGASAWARA SHINYA (JP)
MIURA SHUHEI (JP)
SAITO AKIHIKO (JP)
TAKEDA TETSURO (JP)
MIURA SHUHEI (JP)
SAITO AKIHIKO (JP)
TAKEDA TETSURO (JP)
Application Number:
PCT/JP2007/056660
Publication Date:
October 25, 2007
Filing Date:
March 28, 2007
Export Citation:
Assignee:
UNIV NIIGATA (JP)
DENKA SEIKEN KK (JP)
OGASAWARA SHINYA (JP)
MIURA SHUHEI (JP)
SAITO AKIHIKO (JP)
TAKEDA TETSURO (JP)
DENKA SEIKEN KK (JP)
OGASAWARA SHINYA (JP)
MIURA SHUHEI (JP)
SAITO AKIHIKO (JP)
TAKEDA TETSURO (JP)
International Classes:
G01N33/53; C07K16/18; C12N15/09
Domestic Patent References:
| WO2002091955A1 | 2002-11-21 |
Foreign References:
| JPH04351962A | 1992-12-07 | |||
| JPH08105889A | 1996-04-23 | |||
| US20040204357A1 | 2004-10-14 | |||
| JP2005528615A | 2005-09-22 | |||
| JP2006089306A | 2006-04-06 |
Other References:
DE JONG M. ET AL.: "Megalin Is Essential for Renal Proximal Tubule Reabsorption of 111In-DTPA-Octeotide", THE JOURNAL OF NUCLEAR MEDICINE, vol. 46, no. 10, October 2005 (2005-10-01), pages 1696 - 1700, XP003018805
KERJASCHKI D.; FARQUHAR M.G., PROC. NATL. ACAD. SCI. U.S.A., vol. 79, 1982, pages 5557 - 5561
SAITO A. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 91, 1994, pages 9725 - 9729
CHRISTENSEN E. I.; WILLNOW, T. E., J. AM. SOC. NEPHROL., vol. 10, 1999, pages 2224 - 2236
JUHLIN C.; KLARESKOG L. ET AL., J. BIOL. CHEM., vol. 265, 1990, pages 8275 - 8279
ZHENG G; MCCLUSKEY R. T. ET AL., J. HISTOCHEM. CYTOCHEM., vol. 42, 1994, pages 531 - 542
MAUSBACH A. B.; CHRISTENSEN E. I.: "Handbook of Physiology: Renal Physiology", 1992, OXFORD UNIVERSITY PRESS, pages: 42 - 207
KORENBERG J. R. ET AL., GENOMICS, vol. 22, 1994, pages 88 - 93
HJALM G. ET AL., EUR. J. BIOCHEM., vol. 239, 1996, pages 132 - 137
FARQUHAR M. G. ET AL., J.AM. SOC. NEPHROL., vol. 6, 1995, pages 35 - 47
CHRISTENSEN E. I. ET AL., NAT. REV. MOL. CELL. BIOL., vol. 3, 2002, pages 256 - 266
WILLNOW T. E. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 93, 1996, pages 8460 - 8464
YOCHEM J. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 90, 1993, pages 4572 - 4576
KERJASCHKI D. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 89, 1992, pages 11179 - 11183
SAITO A.; FARQUHAR M. G. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 93, 1996, pages 8601 - 8605
YAMAZAKI H.; FARQUHAR M. G. ET AL., J. AM. SOC. NEPHROL., vol. 9, 1998, pages 1638 - 1644
ORLANDO R. A.; FARQUHAR M. G. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 94, 1997, pages 2368 - 2373
CHRISTENSEN. E. 1. ET AL., NAT. REV. MOL. CELL. BIOL., vol. 3, 2002, pages 256 - 266
CHRISTENSEN E. I.; WILLNOW T. E., J. AM. SOC. NEPHROL., vol. 10, 1999, pages 2224 - 2236
SAITO A.; GEJYO F ET AL., ENDOCRINOLOGY, vol. 145, 2004, pages 3935 - 3940
TARZI R. M.; LORD G. M. ET AL., AM. J. PATHOL., vol. 164, 2004, pages 385 - 390
SAITO A.; GEJYO F. ET AL., J. ARN. SOC. NEPHROL., vol. 14, 2003, pages 1123 - 1131
TAKEDA T.; GEJYO F.; SAITO A. ET AL., LAB. INVEST., vol. 85, 2005, pages 522 - 53 1
OLEINIKOV A. V ET AL., BIOCHEM. J., vol. 347, 2000, pages 613 - 621
RADER K.; FARQUHAR M.G. ET AL., J. AM. SOC. NEPHROL., vol. 11, 2000, pages 2167 - 2178
PATRIE K. M.; MARGOLIS B. ET AL., J. AM. SOC. NEPHROL., vol. 12, 2001, pages 667 - 677
LOU X.; FARQUHAR M.G. ET AL., J. AM. SOC. NEPHROL., vol. 13, 2002, pages 918 - 927
PETERSEN H.H.; WILLNOW T. E., J. CELL. SCI., vol. 116, 2003, pages 453 - 461
TAKEDA T.; FARQUHAR M.G. ET AL., MOL. BIOL. CELL, vol. 14, 2003, pages 4984 - 4996
BIEMESDERFER D. ET AL., J. BIOL. CHEM., vol. 274, 1999, pages 17518 - 17524
HRYCIW D. H ET AL., CLIN. EXP. PHARMACOL. PHYSIOL., vol. 31, 2004, pages 372 - 379
VALLON V. ET AL., J. AM. SOC. NEPHROL., vol. 14, 2003, pages 530 - 537
HRYCIW D. H. ET AL., CLIN. EXP. PHARMACOL. PHYSIOL., vol. 31, 2004, pages 372 - 379
LEHESTE J. ET AL., AM. J. PATHOL., vol. 155, 1999, pages 1361 - 1370
ANTHONY G. W.; MOESTRUP S.K. ET AL., J. AM. SOC. NEPHROL., vol. 13, 2002, pages 125 - 133
GEJYO F.; SCHMID K. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 129, 1985, pages 701 - 706
HENLE T.; MIYATA T., ADV. REN. REPLACE THER., vol. 10, 2003, pages 321 - 331
SAITO A.; TABATA Y.; GEJYO F. ET AL., J. AM. SOC. NEPHROL., vol. 14, 2003, pages 2025 - 2032
ZOU Z.; BIEMESDERFER D. ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 34302 - 34310
GRIGORENKO A. P. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 101, 2004, pages 14955 - 14960
ENGVALL E; PERLMANN P., IMMUNOCHEMISTRY, vol. 8, 1971, pages 871 - 874
JOSEPHY P.D.; MASON R.P. ET AL., J. BIOL. CHEM., vol. 257, 1982, pages 3669 - 3675
BOS E. S. ET AL., J. IMMUNOASSAY, vol. 2, 1981, pages 187 - 204
See also references of EP 2006683A4
KERJASCHKI D.; FARQUHAR M.G., PROC. NATL. ACAD. SCI. U.S.A., vol. 79, 1982, pages 5557 - 5561
SAITO A. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 91, 1994, pages 9725 - 9729
CHRISTENSEN E. I.; WILLNOW, T. E., J. AM. SOC. NEPHROL., vol. 10, 1999, pages 2224 - 2236
JUHLIN C.; KLARESKOG L. ET AL., J. BIOL. CHEM., vol. 265, 1990, pages 8275 - 8279
ZHENG G; MCCLUSKEY R. T. ET AL., J. HISTOCHEM. CYTOCHEM., vol. 42, 1994, pages 531 - 542
MAUSBACH A. B.; CHRISTENSEN E. I.: "Handbook of Physiology: Renal Physiology", 1992, OXFORD UNIVERSITY PRESS, pages: 42 - 207
KORENBERG J. R. ET AL., GENOMICS, vol. 22, 1994, pages 88 - 93
HJALM G. ET AL., EUR. J. BIOCHEM., vol. 239, 1996, pages 132 - 137
FARQUHAR M. G. ET AL., J.AM. SOC. NEPHROL., vol. 6, 1995, pages 35 - 47
CHRISTENSEN E. I. ET AL., NAT. REV. MOL. CELL. BIOL., vol. 3, 2002, pages 256 - 266
WILLNOW T. E. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 93, 1996, pages 8460 - 8464
YOCHEM J. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 90, 1993, pages 4572 - 4576
KERJASCHKI D. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 89, 1992, pages 11179 - 11183
SAITO A.; FARQUHAR M. G. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 93, 1996, pages 8601 - 8605
YAMAZAKI H.; FARQUHAR M. G. ET AL., J. AM. SOC. NEPHROL., vol. 9, 1998, pages 1638 - 1644
ORLANDO R. A.; FARQUHAR M. G. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 94, 1997, pages 2368 - 2373
CHRISTENSEN. E. 1. ET AL., NAT. REV. MOL. CELL. BIOL., vol. 3, 2002, pages 256 - 266
CHRISTENSEN E. I.; WILLNOW T. E., J. AM. SOC. NEPHROL., vol. 10, 1999, pages 2224 - 2236
SAITO A.; GEJYO F ET AL., ENDOCRINOLOGY, vol. 145, 2004, pages 3935 - 3940
TARZI R. M.; LORD G. M. ET AL., AM. J. PATHOL., vol. 164, 2004, pages 385 - 390
SAITO A.; GEJYO F. ET AL., J. ARN. SOC. NEPHROL., vol. 14, 2003, pages 1123 - 1131
TAKEDA T.; GEJYO F.; SAITO A. ET AL., LAB. INVEST., vol. 85, 2005, pages 522 - 53 1
OLEINIKOV A. V ET AL., BIOCHEM. J., vol. 347, 2000, pages 613 - 621
RADER K.; FARQUHAR M.G. ET AL., J. AM. SOC. NEPHROL., vol. 11, 2000, pages 2167 - 2178
PATRIE K. M.; MARGOLIS B. ET AL., J. AM. SOC. NEPHROL., vol. 12, 2001, pages 667 - 677
LOU X.; FARQUHAR M.G. ET AL., J. AM. SOC. NEPHROL., vol. 13, 2002, pages 918 - 927
PETERSEN H.H.; WILLNOW T. E., J. CELL. SCI., vol. 116, 2003, pages 453 - 461
TAKEDA T.; FARQUHAR M.G. ET AL., MOL. BIOL. CELL, vol. 14, 2003, pages 4984 - 4996
BIEMESDERFER D. ET AL., J. BIOL. CHEM., vol. 274, 1999, pages 17518 - 17524
HRYCIW D. H ET AL., CLIN. EXP. PHARMACOL. PHYSIOL., vol. 31, 2004, pages 372 - 379
VALLON V. ET AL., J. AM. SOC. NEPHROL., vol. 14, 2003, pages 530 - 537
HRYCIW D. H. ET AL., CLIN. EXP. PHARMACOL. PHYSIOL., vol. 31, 2004, pages 372 - 379
LEHESTE J. ET AL., AM. J. PATHOL., vol. 155, 1999, pages 1361 - 1370
ANTHONY G. W.; MOESTRUP S.K. ET AL., J. AM. SOC. NEPHROL., vol. 13, 2002, pages 125 - 133
GEJYO F.; SCHMID K. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 129, 1985, pages 701 - 706
HENLE T.; MIYATA T., ADV. REN. REPLACE THER., vol. 10, 2003, pages 321 - 331
SAITO A.; TABATA Y.; GEJYO F. ET AL., J. AM. SOC. NEPHROL., vol. 14, 2003, pages 2025 - 2032
ZOU Z.; BIEMESDERFER D. ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 34302 - 34310
GRIGORENKO A. P. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 101, 2004, pages 14955 - 14960
ENGVALL E; PERLMANN P., IMMUNOCHEMISTRY, vol. 8, 1971, pages 871 - 874
JOSEPHY P.D.; MASON R.P. ET AL., J. BIOL. CHEM., vol. 257, 1982, pages 3669 - 3675
BOS E. S. ET AL., J. IMMUNOASSAY, vol. 2, 1981, pages 187 - 204
See also references of EP 2006683A4
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chome Minato-k, Tokyo 01, JP)
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