Title:
HUMAN RETROVIRUS-SENSITIVE TRANSGENIC NONHUMAN ANIMAL CELL AND HUMAN RETROVIRUS-SENSITIVE TRANSGENIC NONHUMAN ANIMAL MODEL
Document Type and Number:
WIPO Patent Application WO/2005/103246
Kind Code:
A1
Abstract:
A transgenic nonhuman animal cell exhibiting high sensitivity to human retrovirus, such as HIV virus or HTLV-1 virus; and a human retrovirus-sensitive transgenic nonhuman animal model. In particular, there is provided a human retrovirus-sensitive transgenic nonhuman animal in which human CRM1 gene has been introduced in form realizing gene expression, or a human retrovirus-sensitive transgenic nonhuman animal cell in which human CRM1 gene has been introduced in form realizing gene expression.
Inventors:
SHIDA HISATOSHI (JP)
Application Number:
PCT/JP2004/005607
Publication Date:
November 03, 2005
Filing Date:
April 20, 2004
Export Citation:
Assignee:
HOKKAIDO TECH LICENSING OFFICE (JP)
SHIDA HISATOSHI (JP)
SHIDA HISATOSHI (JP)
International Classes:
A01K67/027; C07K14/705; C12N5/10; C12N15/09; C12Q1/02; C12Q1/70; (IPC1-7): C12N15/09; A01K67/027; C12N5/10; C12Q1/70
Other References:
TRONO D. ET AL: "A human cell factor is essential for HIV-1 Rev action", EMBO J., vol. 9, 1990, pages 4155 - 4160, XP002980666
BROWNING J. ET AL: "Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection", PNAS, vol. 94, 1997, pages 14637 - 14641, XP002925294
ASKJAER P. ET AL: "The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP", J. OF BIOLOGICAL CHEMISTRY, vol. 273, no. 50, 11 December 1998 (1998-12-11), pages 33414 - 33422, XP002980667
MARIANI R. ET AL: "A block to human immunodeficiency virus type 1 assembly in murine cells", J. VIROL., vol. 74, no. 8, 2000, pages 3859 - 3870, XP002980668
BROWNING J. ET AL: "Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection", PNAS, vol. 94, 1997, pages 14637 - 14641, XP002925294
ASKJAER P. ET AL: "The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP", J. OF BIOLOGICAL CHEMISTRY, vol. 273, no. 50, 11 December 1998 (1998-12-11), pages 33414 - 33422, XP002980667
MARIANI R. ET AL: "A block to human immunodeficiency virus type 1 assembly in murine cells", J. VIROL., vol. 74, no. 8, 2000, pages 3859 - 3870, XP002980668
Attorney, Agent or Firm:
Hiraki, Yusuke (3-20 Toranomon 4-chom, Minato-ku Saitama, JP)
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