Title:
HUMANIZED ANTIBODY THAT BONDS TO EVA1 PROTEIN OR FUNCTIONAL FRAGMENT THEREOF, ANTIBODY-DRUG CONJUGATE AND CHIMERIC ANTIGEN RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2023/171009
Kind Code:
A1
Abstract:
Provided are a humanized antibody that bonds to an EVA1 protein derived from a human or a functional fragment thereof, an antibody-drug conjugate comprising the humanized antibody or functional fragment thereof, and a chimeric antigen receptor comprising an antibody that bonds to an EVA1 protein derived from a human or a functional fragment thereof.
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Inventors:
MICHISHITA MASAHIRO (JP)
KONDO TORU (JP)
TERAKURA SEITARO (JP)
OSAKI MASAHIDE (JP)
KIYOI HITOSHI (JP)
KONDO TORU (JP)
TERAKURA SEITARO (JP)
OSAKI MASAHIDE (JP)
KIYOI HITOSHI (JP)
Application Number:
PCT/JP2022/036260
Publication Date:
September 14, 2023
Filing Date:
September 28, 2022
Export Citation:
Assignee:
CURED INC (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
International Classes:
A61K39/395; C12N15/13; A61P35/00; C07K16/30; C07K16/46; C07K19/00; C12N5/078; C12N5/10; C12N15/12; C12N15/62; C12N15/63
Domestic Patent References:
| WO2017022668A1 | 2017-02-09 | |||
| WO2022097750A1 | 2022-05-12 |
Other References:
DONINI CHIARA, RAMONA ROTOLO, ALESSIA PROMENT, MASSIMO AGLIETTA, DARIO SANGIOLO, VALERIA LEUCI: "Cellular Immunotherapy Targeting Cancer Stem Cells: Preclinical Evidence and Clinical Perspective", CELLS, vol. 10, no. 3, 4 March 2021 (2021-03-04), pages 543, XP093089008
JAKRAWADEE JULAMANEE, SEITARO TERAKURA, KOJI UMEMURA, YOSHITAKA ADACHI, KOTARO MIYAO, SHINGO OKUNO, ERINA TAKAGI, TOSHIYASU SAKAI,: "Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 29, no. 9, 1 September 2021 (2021-09-01), US , pages 2677 - 2690, XP009536484, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2021.04.038
JAKRAWADEE JULAMANEE, SEITARO TERAKURA, KOJI UMEMURA, YOSHITAKA ADACHI, KOTARO MIYAO, SHINGO OKUNO, ERINA TAKAGI, TOSHIYASU SAKAI,: "Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 29, no. 9, 1 September 2021 (2021-09-01), US , pages 2677 - 2690, XP009536484, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2021.04.038
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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