Title:
HYALURONIC ACID DERIVATIVE OR SALT THEREOF, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/134613
Kind Code:
A1
Abstract:
A hyaluronic acid derivative or a salt thereof, and a preparation method therefor and an application thereof. Hyaluronic acid is used as a matrix skeleton, and a methoxypolyethylene glycol epoxy derivative is used to modify hyaluronic acid to prepare a pegylated hyaluronic acid derivative. The skeleton of hyaluronic acid is wound by using polyethyleneglycol linear macromolecules, so that a glycosidic bond facilitating enzymolysis is masked, a circulation duration of sodium hyaluronate in the body is prolonged, and the moisture retention and moisture lock effect can be better exerted. Meanwhile, polyethyleneglycol and sodium hyaluronate, serving as artificially synthesized and naturally existing high polymer materials, both have good biocompatibility and biodegradability, and are combined, so that the advantages of the high polymer material can be better exerted.
Inventors:
LIN MEINA (CN)
CHEN XIAOMENG (CN)
SUN YU (CN)
ZHAO XUAN (CN)
CHEN XIAOMENG (CN)
SUN YU (CN)
ZHAO XUAN (CN)
Application Number:
PCT/CN2023/071208
Publication Date:
July 20, 2023
Filing Date:
January 09, 2023
Export Citation:
Assignee:
JENKEM TECH CO LTD TIANJIN (CN)
International Classes:
A61L27/20; C08J3/075; A61L27/50; C08G59/04; C08J3/24; C08L5/08
Foreign References:
| CN107880282A | 2018-04-06 | |||
| CN109096483A | 2018-12-28 | |||
| CN103360633A | 2013-10-23 | |||
| CN111423591A | 2020-07-17 |
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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