Title:
HYALURONIC ACID/METHOTREXATE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2005/095464
Kind Code:
A1
Abstract:
A hyaluronic acid/methotrexate compound useful as a therapeutic agent for joint diseases. The hyaluronic acid/methotrexate compound useful for the treatment of joint diseases comprises hyaluronic acid and methotrexate bonded to a hydroxy group of the acid through a linker having a peptide chain comprising one to eight amino acids, the linker being bonded to the hyaluronic acid through a carbamate group.
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Inventors:
IKEYA HITOSHI (JP)
MORIKAWA TADASHI (JP)
TAKAHASHI KOICHI (JP)
IZUTANI NORIYUKI (JP)
TAMURA TATSUYA (JP)
OKAMACHI AKIRA (JP)
ISHIZAWA TAKENORI (JP)
SATO HARUHIKO (JP)
HIGUCHI YOSHINOBU (JP)
KATO TATSUYA (JP)
HONMA AKIE (JP)
MORIKAWA TADASHI (JP)
TAKAHASHI KOICHI (JP)
IZUTANI NORIYUKI (JP)
TAMURA TATSUYA (JP)
OKAMACHI AKIRA (JP)
ISHIZAWA TAKENORI (JP)
SATO HARUHIKO (JP)
HIGUCHI YOSHINOBU (JP)
KATO TATSUYA (JP)
HONMA AKIE (JP)
Application Number:
PCT/JP2005/006472
Publication Date:
October 13, 2005
Filing Date:
April 01, 2005
Export Citation:
Assignee:
DENKI KAGAKU KOGYO KK (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
IKEYA HITOSHI (JP)
MORIKAWA TADASHI (JP)
TAKAHASHI KOICHI (JP)
IZUTANI NORIYUKI (JP)
TAMURA TATSUYA (JP)
OKAMACHI AKIRA (JP)
ISHIZAWA TAKENORI (JP)
SATO HARUHIKO (JP)
HIGUCHI YOSHINOBU (JP)
KATO TATSUYA (JP)
HONMA AKIE (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
IKEYA HITOSHI (JP)
MORIKAWA TADASHI (JP)
TAKAHASHI KOICHI (JP)
IZUTANI NORIYUKI (JP)
TAMURA TATSUYA (JP)
OKAMACHI AKIRA (JP)
ISHIZAWA TAKENORI (JP)
SATO HARUHIKO (JP)
HIGUCHI YOSHINOBU (JP)
KATO TATSUYA (JP)
HONMA AKIE (JP)
International Classes:
A61K31/519; A61K47/48; A61P19/02; C07D475/08; C08B37/08; C07D475/10; C07K5/00; (IPC1-7): C08B37/08; A61K31/519; A61K47/48; A61P19/02
Foreign References:
| JPH0539306A | 1993-02-19 | |||
| JPH11222425A | 1999-08-17 | |||
| JPH09188705A | 1997-07-22 | |||
| JPH0680705A | 1994-03-22 | |||
| JPH0885703A | 1996-04-02 | |||
| JPS6440499A | 1989-02-10 |
Other References:
ROSOWSKY A. ET AL: "Methotrexate analogs. 22. Synthesis, Dihydrofolate Reductase Affinity, Cytotoxicity, and in Vivo Antitumor Activity of Some Putative Degradation Products of Methotrexate-Poly(L-lysine)Conjugates.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 27, no. 7, 1984, pages 888 - 893, XP002989867
See also references of EP 1739097A4
See also references of EP 1739097A4
Attorney, Agent or Firm:
Shamoto, Ichio (Section 206 New Ohtemachi Bldg., 2-1,
Ohtemachi 2-chom, Chiyoda-ku Tokyo, JP)
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