HYDROPHOBIC METHYLENE BLUE FLUORESCENT DYE, PREPARATION METHOD THEREFOR AND USE THEREOF

WIPO Patent Application WO/2023/173824

A1

Disclosed in the present invention are a hydrophobic methylene blue fluorescent dye, and a preparation method therefor and the use thereof. The hydrophobic methylene blue fluorescent dye has a structural formula as shown in formula (I), can effectively release ROS for photodynamic therapy or participating in subsequent reactions, can emit strong fluorescence at 650 nm for tumor imaging, has AIE properties, can enhance the luminescence, and has a strong hydrophobicity, allowing for easy encapsulation in order to form a nanoparticle, and thereby enhancing the transporting and targeting functions.

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GONG PING (CN)
MA GONGCHENG (CN)
LIU ZHONGKE (CN)
CAI LINTAO (CN)
ZHANG PENGFEI (CN)

PCT/CN2022/137054

September 21, 2023

December 06, 2022

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SHENZHEN INST ADV TECH (CN)

A61K9/51; C07D279/18; A61K41/00; A61K47/54; A61K47/69; A61K49/00; A61P35/00; C09B21/00; C09K11/06

CN114806211A	2022-07-29
CN114656424A	2022-06-24
CN102718730A	2012-10-10
CN110856747A	2020-03-03
CN107501297A	2017-12-22
CN102552939A	2012-07-11
CN113264904A	2021-08-17

BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)

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