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Title:
INHIBITORS OF FACTOR Xa
Document Type and Number:
WIPO Patent Application WO2000071510
Kind Code:
A3
Abstract:
Compounds of formula A - Y - D - E - G - J - Z - L in which D is direct link, a substutited or unsubstituted phenyl or napththyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions relating thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

Inventors:
SU TING
ZHU BING-YAN
KANE-MAGUIRE KIM
SCARBOROUGH ROBERT M
ZHANG PENGLIE
Application Number:
PCT/US2000/014195
Publication Date:
August 30, 2001
Filing Date:
May 24, 2000
Export Citation:
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Assignee:
COR THERAPEUTICS INC (US)
International Classes:
C07D213/74; A61K31/18; A61K31/198; A61K31/341; A61K31/397; A61K31/40; A61K31/401; A61K31/4164; A61K31/44; A61K31/4406; A61K31/4427; A61K31/4453; A61K31/472; A61K31/4725; A61K31/495; A61K31/496; A61K31/5375; A61K31/55; A61P7/02; A61P9/00; A61P9/10; A61P43/00; C07C311/16; C07C311/21; C07C311/46; C07D205/04; C07D207/16; C07D207/20; C07D207/325; C07D213/40; C07D213/64; C07D213/72; C07D213/75; C07D213/82; C07D217/22; C07D231/12; C07D233/68; C07D295/18; C07D295/192; C07D295/22; C07D295/26; C07D307/38; C07D307/52; C07D401/12; (IPC1-7): C07C311/46; C07D213/74; C07D295/18; C07D207/16; C07D205/04; C07D207/22; C07D295/26; C07D295/22; C07D233/68; C07D207/32; C07D231/12; C07D217/22; A61K31/18; A61K31/33; A61P7/02
Domestic Patent References:
WO1998057934A11998-12-23
WO1998028282A21998-07-02
WO1998028269A11998-07-02
Foreign References:
US3235597A1966-02-15
DE1062253B1959-07-30
Other References:
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D.H.R. BARTON, ET AL.: "The catalytic effect of copper ions in the phenylation reaction of David and Thieffry", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, no. 1, January 1986 (1986-01-01), Royal Society of Chemistry, Letchworth, GB, pages 65 - 66, XP002161082, ISSN: 0022-4936
L.W. DEADY, ET AL.: "A new synthesis of N-arylazetidines", TETRAHEDRON LETTERS, no. 14, 1968, Elsevier Science Publishers, Amsterdam, NL, pages 1773 - 1776, XP002161083, ISSN: 0040-4039
G.F. GRILLOT, ET AL.: "Condesation of thiophenols and formaldehyde with some aromatic amines", JOURNAL OF ORGANIC CHEMISTRY, vol. 24, no. 8, 31 August 1959 (1959-08-31), American Chemical Society, Washington, DC, US, pages 1035 - 1038, XP002161084, ISSN: 0022-3263
E. BÄDER, ET AL.: "Neue Methoden zur Darstellung von Sufonaminen (IV. Mitteil.: Polymerisationen und Polymerisationskatalysatoren)", CHEMISCHE BERICHTE, vol. 88, no. 1, 1955, Verlag Chemie, Weinheim, DE, pages 41 - 49, XP002161085, ISSN: 0009-2940
S.T. MCDOWELL, ET AL.: "Elimination-addition. Part XI. Electronic effects upon the reactivity of aryl vinyl sulphones towards amines", JOURNAL OF THE CHEMICAL SOCIETY, SECTION B: PHYSICAL ORGANIC CHEMISTRY., no. 5, May 1967 (1967-05-01), Royal Society of Chemistry, Letchworth, GB, pages 348 - 350, XP002161086
A.W.M. LEE, ET AL.: "A facile total synthesis of isoquinoline alkaloids", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, no. 3, 1992, Royal Society of Chemistry, Letchworth, GB, pages 309 - 310, XP002161087, ISSN: 0300-922X
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