Title:
IL-6 PRODUCTION INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2002/074298
Kind Code:
A1
Abstract:
IL-6 production inhibitors containing as the active ingredient hydroxamic acid derivatives represented by the following general formula (I) or equivalents thereto, non-toxic salts thereof or prodrugs of the same, (I) wherein each symbol is as defined in the description. Because of having an IL-6 production inhibitory activity, the compounds of the general formula (I) are useful as preventives and/or remedies for various inflammatory diseases, sepsis, multiple myeloma, plasmacytoid leukemia, osteoporosis, cachexia, psoriasis, nephritis, kidney cell cancer, Kaposi's sarcoma, rheumatoid arthritis, hypergamma globulinemia, Castleman's disease, intra-atrial myxoma, diabetes, autoimmune diseases, hepatitis, colitis, graft-versus-host disease, infections, endometriosis and solid cancer.
Inventors:
NAKA MASAO (JP)
TAKAHASHI KANJI (JP)
TAKAHASHI KANJI (JP)
Application Number:
PCT/JP2002/002681
Publication Date:
September 26, 2002
Filing Date:
March 20, 2002
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
NAKA MASAO (JP)
TAKAHASHI KANJI (JP)
NAKA MASAO (JP)
TAKAHASHI KANJI (JP)
International Classes:
A61K31/16; A61K31/165; A61K31/166; A61K31/167; A61K31/18; A61K31/27; A61K31/277; A61K31/336; A61K31/343; A61K31/381; A61K31/44; A61K31/4409; A61K31/505; A61K31/5375; A61K31/662; A61P3/10; A61P19/10; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07C259/06; C07C311/19; C07C311/21; C07C317/44; C07C323/16; C07C323/60; C07C327/28; C07D317/30; C07F9/38; C07F9/40; C07F9/59; C07F9/6509; C07F9/6533; (IPC1-7): A61K31/166; A61K31/165; A61K31/167; A61K31/18; A61K31/27; A61K31/277; A61K31/336; A61K31/343; A61K31/381; A61K31/44; A61K31/4409; A61K31/505; A61K31/5375; A61K31/662; A61P3/10; A61P19/10; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07C235/34; C07C243/32; C07C259/06; C07C259/10; C07C271/22; C07C311/19; C07C311/21; C07C317/40; C07C323/16; C07C323/52; C07C327/28; C07D213/56; C07D213/82; C07D295/14; C07D303/32; C07D307/80; C07D317/16; C07D317/20; C07D317/22; C07D319/06; C07D333/40; C07D333/60
Domestic Patent References:
| WO1997008133A1 | 1997-03-06 | |||
| WO1999061413A1 | 1999-12-02 | |||
| WO1999019296A1 | 1999-04-22 | |||
| WO1997018188A1 | 1997-05-22 | |||
| WO1999011608A1 | 1999-03-11 | |||
| WO1997043239A1 | 1997-11-20 | |||
| WO2001021583A1 | 2001-03-29 |
Foreign References:
| JPH09124571A | 1997-05-13 | |||
| EP0757984A1 | 1997-02-12 | |||
| JPH10182583A | 1998-07-07 |
Attorney, Agent or Firm:
Ohie, Kunihisa (Horiguchi No.2 Bldg. 7F 2-6,
Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo, JP)
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