TNF$g(a) PRODUCTION INHIBITORS

Title:

TNF$g(a) PRODUCTION INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2002/074299

Kind Code:

A1

Abstract:

Medicinal compositions containing aminomethanesulfonic acid (involving salts and esters thereof) as the active ingredient. Because of being superior in the effect of inhibiting TNFa production to glycine having been proposed hitherto, these compositions are expected as useful as drugs for liver diseases. Moreover, utilization of the above active ingredients in drugs, a method of inhibiting TNFa production and, in particular, a method of treating, ameliorating and/or preventing liver diseases with the use of the above method are provided.

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Inventors:

ISHIZAKI SONOKO (JP)
SONAKA ICHIRO (JP)
IINO YUKIO (JP)

Application Number:

PCT/JP2001/011112

Publication Date:

September 26, 2002

Filing Date:

December 18, 2001

Export Citation:

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Assignee:

AJINOMOTO KK (JP)
ISHIZAKI SONOKO (JP)
SONAKA ICHIRO (JP)
IINO YUKIO (JP)

International Classes:

A61K31/185; A61K31/255; A61P1/16; A61P43/00; (IPC1-7): A61K31/185; A61K31/255; A61P1/16; A61P43/00

Domestic Patent References:

WO1995014457A1

1995-06-01

Other References:

LOMBARDINI JOHN B. ET AL: "Inhibition of the synthesis of taurocholic acid by structural analogs of taurine", BIOCHEM. PHARMACOL., vol. 26, no. 12, 1977, pages 1175 - 1177, XP002908295
See also references of EP 1356810A4

Attorney, Agent or Firm:

Ishida, Yasumasa (7th Floor 20-12, Shin-Yokohama 3-chom, Kohoku-ku Yokohama-shi Kanagawa, JP)

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