Title:
IMMUNE CHECKPOINT INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/009438
Kind Code:
A1
Abstract:
The present invention provides a novel immune checkpoint inhibitor which has not been reported before. Provided is an immune checkpoint inhibitor which is characterized by including, as an active ingredient, a plant fermentation product which is a mixture of the fermentation products in (a) to (g): (a) a koji mold fermentation product of one or more beans or grains selected from the group consisting of barley, black soybeans, red rice, black rice, adzuki beans, adlay, Japanese barnyard millet, foxtail millet, and proso millet; (b) a yeast and/or lactic acid bacteria fermentation product of one or more fruits selected from the group consisting of mandarin oranges, grapes, apples, Vitis coignetiae berries, peaches, persimmons, papayas, Japanese pears, watermelons, Japanese apricots, figs, Chinese quince fruit, kabocha squash, kumquats, yuzu, loquat fruit, apricots, jujubes, chestnuts, matatabi fruit, and Japanese plums; (c) a yeast and/or lactic acid bacteria fermentation product of one or more root vegetables/potatoes selected from the group consisting of purple sweet potatoes, Jerusalem artichokes, carrots, onions, sweet potatoes, taros, Japanese wild yam, daikon, red turnips, great burdock, lotus roots, yacón, lily bulbs, arrowhead, ginger, garlic, and turmeric; (d) a yeast and/or lactic acid bacteria fermentation product of one or more flowers/leafy vegetables selected from the group consisting of cabbage, perilla, Morus leaves, fish mint, Japanese mugwort, Sasa veitchii, and dandelions; (e) a yeast and/or lactic acid bacteria fermentation product of one or more types of seaweed selected from the group consisting of kelp, wakame, and mozuku; (f) a yeast and/or lactic acid bacteria fermentation product of one or more seeds selected from the group consisting of black sesame, walnuts, and ginkgo nuts; and (g) a yeast and/or lactic acid bacteria fermentation product of one or more mushrooms selected from the group consisting of maitake and shiitake.
Inventors:
HIGASHI NAOKI (JP)
NAKANISHI MASAHIRO (JP)
NAKANISHI MASAHIRO (JP)
Application Number:
PCT/JP2018/035179
Publication Date:
January 10, 2019
Filing Date:
September 21, 2018
Export Citation:
Assignee:
NIHON SIZEN HAKKOH CO LTD (JP)
International Classes:
A23L11/20; A23L17/60; A23L19/00; A23L19/10; A23L29/206; A23L29/256; A23L31/15; A61K31/19; A61K36/03; A61K36/062; A61K36/07; A61K36/16; A61K36/185; A61K36/28; A61K36/282; A61K36/288; A61K36/29; A61K36/31; A61K36/39; A61K36/42; A61K36/44; A61K36/46; A61K36/49; A61K36/52; A61K36/535; A61K36/60; A61K36/70; A61K36/725; A61K36/73; A61K36/732; A61K36/736; A61K36/744; A61K36/75; A61K36/752; A61K36/87; A61K36/888; A61K36/894; A61K36/896; A61K36/8962; A61K36/8988; A61K36/899; A61K36/8994; A61K36/9066; A61K36/9068; A61P35/00; A61P43/00
Domestic Patent References:
| WO2016093104A1 | 2016-06-16 | |||
| WO2017167213A1 | 2017-10-05 | |||
| WO2002072123A1 | 2002-09-19 | |||
| WO2006093267A1 | 2006-09-08 |
Foreign References:
| JP2007084504A | 2007-04-05 | |||
| JP2006117575A | 2006-05-11 | |||
| JP2015202065A | 2015-11-16 | |||
| JP2013237652A | 2013-11-28 | |||
| JP2007230973A | 2007-09-13 | |||
| JPH09169661A | 1997-06-30 | |||
| JP2002138046A | 2002-05-14 | |||
| JP2007319157A | 2007-12-13 | |||
| JP2008255057A | 2008-10-23 | |||
| JP2004107286A | 2004-04-08 | |||
| JPS6013670B2 | 1985-04-09 | |||
| JP2018034617W | 2018-09-19 |
Other References:
CHOWDHURY PSCHAMOTO KHONJO T: "Combination therapy strategies for improving PD-1 blockade efficacy: a new era in cancer immunotherapy", J. INTERM MED, vol. 283, no. 2, February 2018 (2018-02-01), pages 110 - 120, XP055703710, DOI: 10.1111/joim.12708
"experimental medical science", vol. 36, 2018, YODOSHA, article "Gan wa Menekikei wo Ikani Yokusei Surunoka (how a cancer suppresses immune system"
"special issue of experimental medical science", vol. 34, 2016, YODOSHA, article "Gan Menekiryoho - Syuyo Menekigaku no Saishinchiken kara Chiryoho no Appudeito made - (cancer immunotherapy - from the latest findings in tumor immunology to update of the therapy"
See also references of EP 3854224A4
"experimental medical science", vol. 36, 2018, YODOSHA, article "Gan wa Menekikei wo Ikani Yokusei Surunoka (how a cancer suppresses immune system"
"special issue of experimental medical science", vol. 34, 2016, YODOSHA, article "Gan Menekiryoho - Syuyo Menekigaku no Saishinchiken kara Chiryoho no Appudeito made - (cancer immunotherapy - from the latest findings in tumor immunology to update of the therapy"
See also references of EP 3854224A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY OF ONO & CO. (JP)
Download PDF:
Previous Patent: PROPHYLACTIC AGENT FOR SPONTANEOUS CANCERS
Next Patent: ONLINE BUSINESS BROKERAGE SYSTEM AND BUSINESS BROKERAGE METHOD USING SAME
Next Patent: ONLINE BUSINESS BROKERAGE SYSTEM AND BUSINESS BROKERAGE METHOD USING SAME