Title:
IMPROVED ORAL DELIVERY OF PEPTIDES USING ENZYME-CLEAVABLE MEMBRANE TRANSLOCATORS
Document Type and Number:
WIPO Patent Application WO2002043767
Kind Code:
A8
Abstract:
Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine in addition to having the active peptide linked to a membrane translocator which is capable of being at least partially cleaved in vivo by an enzyme. The composition includes an acid-resistant protective vehicle which transports components of the invention through the stomach and a sufficient amount of a pH-lowering agent to lower local intestinal pH. All components are released together into the intestine with the peptide.
Inventors:
STERN WILLIAM
MEHTA NOZAR M
RAY MARTHA V L
MEHTA NOZAR M
RAY MARTHA V L
Application Number:
PCT/US2001/044980
Publication Date:
April 10, 2003
Filing Date:
November 30, 2001
Export Citation:
Assignee:
UNIGENE LAB INC (US)
International Classes:
A61K9/16; A61K9/48; A61K38/00; A61K38/22; A61K38/23; A61K38/26; A61K38/28; A61K47/12; A61K47/14; A61K47/18; A61K47/24; A61K47/30; A61K47/42; A61K47/48; A61K49/08; A61K49/10; A61K49/12; A61K49/14; A61K49/18; A61P3/08; A61P3/10; A61P3/14; A61P5/18; A61P5/48; (IPC1-7): A61K47/30; A61K47/42; A61K47/48; A61K49/08; A61K49/10; A61K49/12; A61K49/18; A61K49/14
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