Title:
INDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/163140
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a compound that exhibits an H-PGDS inhibitory activity. The present invention relates to a compound expressed by formula [I] or a pharmaceutically acceptable salt thereof (in the formula, each reference sign is as defined in the specification).
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Inventors:
NAGAMOTO YUKI (JP)
TAKAGI MASAKI (JP)
MATSUMURA KOJI (JP)
ITO HIROTSUGU (JP)
ITO KEISUKE (JP)
OYAMA YUKI (JP)
TAKAGI MASAKI (JP)
MATSUMURA KOJI (JP)
ITO HIROTSUGU (JP)
ITO KEISUKE (JP)
OYAMA YUKI (JP)
Application Number:
PCT/JP2023/006921
Publication Date:
August 31, 2023
Filing Date:
February 27, 2023
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
International Classes:
C07D403/04; A61K31/416; A61K31/4439; A61K31/444; A61K31/506; A61K31/5377; A61P9/00; A61P11/00; A61P11/06; A61P21/00; A61P37/08; C07D231/56; C07D401/04; C07D401/14; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D451/04; C07D471/04
Domestic Patent References:
| WO2021256569A1 | 2021-12-23 | |||
| WO2022194781A1 | 2022-09-22 |
Foreign References:
| JP2021534166A | 2021-12-09 |
Other References:
TRUJILLO, JOHN I. ET AL.: "Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 11, 2012, pages 3795 - 3799, XP028423366, DOI: 10.1016/j.bmcl. 2012.04.00 4
CHRIST, ANGELIKA N. ET AL.: "Development and Characterization of New Inhibitors of the Human and Mouse Hematopoietic Prostaglandin D2 Synthases", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 15, 2010, pages 5536 - 5548, XP055002058, DOI: 10.1021/jm100194a
CHRIST, ANGELIKA N. ET AL.: "Development and Characterization of New Inhibitors of the Human and Mouse Hematopoietic Prostaglandin D2 Synthases", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 15, 2010, pages 5536 - 5548, XP055002058, DOI: 10.1021/jm100194a
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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