INDENE DERIVATIVES - CHUGAI PHARMACEUTICAL CO LTD

Title:

INDENE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1998/057924

Kind Code:

A1

Abstract:

Compounds represented by the general formula (I) (wherein R�1? represents hydrogen etc.; R�2? represents hydrogen etc.; R�3? represents a C�1?-C�3? linear or branched alkyl; and R�4? represents an optionally substituted aryl etc.), hydrates thereof, and pharmaceutically acceptable salts of both. These compounds have COX-2 inhibitory activities and are useful as medicines such as an antiphlogistic.

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Inventors:

MATSUOKA HIROHARU (JP)
MARUYAMA NORIAKI (JP)
KATO YASUHARU (JP)

Application Number:

PCT/JP1998/002611

Publication Date:

December 23, 1998

Filing Date:

June 15, 1998

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Assignee:

CHUGAI PHARMACEUTICAL CO LTD (JP)
MATSUOKA HIROHARU (JP)
MARUYAMA NORIAKI (JP)
KATO YASUHARU (JP)

International Classes:

C07C317/14; C07D213/80; C07D307/68; C07D333/28; (IPC1-7): C07C317/14; A61K31/10; A61K31/12; A61K31/215; A61K31/34; A61K31/38; A61K31/44; C07C317/22; C07C317/24; C07C317/44; C07D213/79; C07D307/68; C07D333/28

Foreign References:

JPS4716445A

Attorney, Agent or Firm:

Tsukuni, Hajime (22-12 Toranomon 1-chom, Minato-ku Tokyo, JP)

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