INDOLINE COMPOUND AND PROCESS FOR PRODUCING THE SAME

Title:

INDOLINE COMPOUND AND PROCESS FOR PRODUCING THE SAME

Document Type and Number:

WIPO Patent Application WO/2006/046499

Kind Code:

A1

Abstract:

A process for industrially producing silodosin, which is a therapeutic agent for urination disorders accompanying prostatic hypertrophy. The process for silodosin production is characterized by mixing 3-&lcub 7-cyano-5-[(2R)-2-(&lcub 2[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl&rcub amino)propyl]-2,3dihydro-1H-indol-1-yl&rcub propyl benzoate with oxalic acid to yield an oxalate, subsequently hydrolyzing the oxalate to yield 1-(3-hydroxypropyl)-5-[(2R)-2-(&lcub 2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl&rcub amino)propyl]-2,3-dihydro-1H-indole-7-carbonitrile, and hydrolyzing it. Also provided is an intermediate for use in the production.

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Inventors:

YAMAGUCHI TOSHIAKI (JP)
TSUCHIYA IKUO (JP)
KIKUCHI KEN (JP)
YANAGI TAKASHI (JP)

Application Number:

PCT/JP2005/019478

Publication Date:

May 04, 2006

Filing Date:

October 24, 2005

Export Citation:

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Assignee:

KISSEI PHARMACEUTICAL (JP)
YAMAGUCHI TOSHIAKI (JP)
TSUCHIYA IKUO (JP)
KIKUCHI KEN (JP)
YANAGI TAKASHI (JP)

International Classes:

C07D209/42

Foreign References:

JPH06220015A	1994-08-09
JP2001199956A	2001-07-24
JP2002265444A	2002-09-18
JPH07165684A	1995-06-27

Other References: