Title:
NOVEL PPAR REGULATING AGENT AND METHOD OF SCREENING THE SAME
Document Type and Number:
WIPO Patent Application WO/2006/046492
Kind Code:
A1
Abstract:
A highly efficient method of screening drugs for diabetes treatment; and novel compounds for treatment and prevention of PPAR-associated diseases. There is provided a method of identifying a compound capable of regulating peroxisome proliferator activated receptor (PPAR), which compound has at least one activity selected from the group consisting of the activity of promoting the insulin secretion of pancreatic β-cells and the activity of promoting peripheral insulin sensitivity. This method comprises the steps of (A) providing candidate compounds; (B) with respect to the candidate compounds, measuring at least one activity selected from the group consisting of the activity of promoting the insulin secretion of pancreatic β-cells and the activity of promoting peripheral insulin sensitivity; (C) subjecting the candidate compounds to an assay for measuring the activity of PPAR; and (D) identifying those judged as having an activity in each of the steps (B) and (C) as lead compounds.
Inventors:
SHIMOMURA IICHIRO (JP)
Application Number:
PCT/JP2005/019431
Publication Date:
May 04, 2006
Filing Date:
October 21, 2005
Export Citation:
Assignee:
UNIV OSAKA (JP)
INTELLECTUAL PROPERTY CONSULTI (JP)
SHIMOMURA IICHIRO (JP)
INTELLECTUAL PROPERTY CONSULTI (JP)
SHIMOMURA IICHIRO (JP)
International Classes:
A61K31/64; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P15/08; A61P17/06; A61P25/00; A61P27/02; A61P29/00; A61P43/00; G01N33/15; G01N33/50; G01N33/74
Domestic Patent References:
| WO2002100413A1 | 2002-12-19 |
Foreign References:
| JP2001510158A | 2001-07-31 | |||
| JPH0967271A | 1997-03-11 | |||
| JP2004513076A | 2004-04-30 | |||
| JP2002332266A | 2002-11-22 |
Other References:
KABADI U. ET AL: "Effects of glimepiride on insulin secretion and sensitivity in patients with recently diagnosed type 2 diabetes mellitus", CLINICAL THERAPEUTICS, vol. 26, no. 1, January 2004 (2004-01-01), pages 63 - 69, XP002992882
TSUNEKAWA T. ET AL: "Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects", DIABETES CARE, vol. 26, no. 2, 2003, pages 285 - 289, XP002993865
AMMARI F. ET AL: "The effect of gliclazide on plasma insulin,intact and 32/33 split proinsulin in South Asian subjects with Type 2 diabetes mellitus", DIABETIC MEDICINE, vol. 16, no. 2, 1999, pages 142 - 146, XP002993866
TSUNEKAWA T. ET AL: "Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects", DIABETES CARE, vol. 26, no. 2, 2003, pages 285 - 289, XP002993865
AMMARI F. ET AL: "The effect of gliclazide on plasma insulin,intact and 32/33 split proinsulin in South Asian subjects with Type 2 diabetes mellitus", DIABETIC MEDICINE, vol. 16, no. 2, 1999, pages 142 - 146, XP002993866
Attorney, Agent or Firm:
Yamamoto, Shusaku (Crystal Tower 2-27, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka 15, JP)
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