INFLAMMATORY BOWEL DISEASE THERAPEUTIC AGENT OR PROPHYLACTIC AGENT

Title:

INFLAMMATORY BOWEL DISEASE THERAPEUTIC AGENT OR PROPHYLACTIC AGENT

Document Type and Number:

WIPO Patent Application WO/2019/022234

Kind Code:

A1

Abstract:

The purpose of the present invention is to provide an inflammatory bowel disease therapeutic agent or prophylactic agent that has an RORγ antagonist activity. In order to achieve this purpose, the present invention provides an inflammatory bowel disease therapeutic agent or prophylactic agent that contains, as an active ingredient, a cyclic amine derivative represented by the indicated compound or a pharmacologically acceptable salt thereof.

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Inventors:

HAYASHI SHINNOSUKE (JP)
VALLET MARTIAL (JP)
YOKOSAKA SHINYA (JP)
OSUMI KAZUYA (JP)
AOKI TAKUMI (JP)
MEGURO HIROYUKI (JP)
KAINO MIE (JP)
TAKAGAKI KOZUE (JP)
TAKAHASHI TAKEHIRO (JP)

Application Number:

PCT/JP2018/028276

Publication Date:

January 31, 2019

Filing Date:

July 27, 2018

Export Citation:

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Assignee:

TORAY INDUSTRIES (JP)

International Classes:

A61K31/445; A61K31/4525; A61K31/454; A61P1/04; A61P43/00

Domestic Patent References:

WO2015103507A1	2015-07-09
WO2015103508A1	2015-07-09
WO2017131156A1	2017-08-03

Foreign References:

JP2015514794A	2015-05-21
JP2015521193A	2015-07-27

Other References:

FAUBER, B. P. ET AL.: "Discovery of 1-{4-[3-Fluoro-4((3S, 6R)-3-methyl-1, 1-dioxo-6-phenyl-[1, 2]thiazinan-2- ylmethyl)-phenyl]-piperazin-1-yl}-ethanone(GNE-3500): a potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORy) Inverse Agonist", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 13, 23 June 2015 (2015-06-23), pages 5308 - 5322, XP055519638

Attorney, Agent or Firm:

NAGAI Hiroshi et al. (JP)

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