Title:
INHIBITOR OF NEUTROPHIL ACTIVATION/MIGRATION FACTOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/129618
Kind Code:
A1
Abstract:
Ribose and 2-deoxyribose can inhibit a neutrophil activation/migration factor, and
is therefore effective for the prevention or treatment of ischemia reperfusion injury.
Ribose and 2-deoxyribose can also inhibit a neutrophil adherence factor in
an organ preservation solution, and is therefore also effective for the enhancement of
amelioration or the treatment of a renal dysfunction occurring after renal transplantation.
Therefore, ribose and 2-deoxyribose can be used as an inhibitor for inhibiting
a neutrophil activation/migration factor or a neutrophil adhesion, or the like.
Inventors:
UEKI MASAAKI
Application Number:
PCT/JP2007/059213
Publication Date:
November 15, 2007
Filing Date:
April 27, 2007
Export Citation:
Assignee:
UNIV KAGAWA NAT UNIV CORP (JP)
UEKI MASAAKI
UEKI MASAAKI
International Classes:
A61K31/7004; A23L1/30; A61P3/10; A61P7/02; A61P7/04; A61P9/02; A61P9/04; A61P9/10; A61P13/02; A61P13/12; A61P17/02; A61P31/00; A61P41/00; A61P43/00; C07H3/02; C07H3/08
Domestic Patent References:
| WO2005027660A2 | 2005-03-31 |
Foreign References:
| JP2003532679A | 2003-11-05 | |||
| JP2004505056A | 2004-02-19 | |||
| JP2002519328A | 2002-07-02 | |||
| JPH09500380A | 1997-01-14 | |||
| JP2000512625A | 2000-09-26 | |||
| JP2002520290A | 2002-07-09 | |||
| JP2004511497A | 2004-04-15 |
Other References:
SMOLENSKI R.T. ET AL.: "Enhanced endogenous adenosine protects from reperfusion injury after heart transplantation", TRANSPLANTATION PROCEEDINGS, vol. 33, 2001, pages 924 - 925, XP003016956
SMOLENSKI R.T. ET AL.: "Protection from reperfusion injury after cardiac transplantation by inhibition of adenosine metabolism and nucleotide precursor supply", CIRCULATION, vol. 104, no. 12, SUPPL., 2001, pages I246 - I252, XP003016957
SMOLENSKI R.T. ET AL.: "Protection of the heart from reperfusion injury and rejection following transplantation by enhanced endogenous adenosine production", CIRCULATION, vol. 102, no. 18, SUPPL., 2000, pages II.739 + ABSTR. NO. 3574, XP003016958
MUELLER C. ET AL.: "Effect of ribose on cardiac adenine nucleotides in a donor model for heart transplantation", EUROPEAN JOURNAL OF MEDICAL RESEARCH, vol. 3, no. 12, 1998, pages 554 - 558, XP003016959
SMOLENSKI R.T. ET AL.: "Protection from reperfusion injury after cardiac transplantation by inhibition of adenosine metabolism and nucleotide precursor supply", CIRCULATION, vol. 104, no. 12, SUPPL., 2001, pages I246 - I252, XP003016957
SMOLENSKI R.T. ET AL.: "Protection of the heart from reperfusion injury and rejection following transplantation by enhanced endogenous adenosine production", CIRCULATION, vol. 102, no. 18, SUPPL., 2000, pages II.739 + ABSTR. NO. 3574, XP003016958
MUELLER C. ET AL.: "Effect of ribose on cardiac adenine nucleotides in a donor model for heart transplantation", EUROPEAN JOURNAL OF MEDICAL RESEARCH, vol. 3, no. 12, 1998, pages 554 - 558, XP003016959
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (2-6 Tenjinbashi 2-chome Kita, Kita-k, Osaka-shi Osaka 41, JP)
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