Title:
INHIBITORS OF BRUTON'S TYROSINE KINASE
Document Type and Number:
WIPO Patent Application WO/2016/004280
Kind Code:
A3
Abstract:
Described herein are heteroaryl compounds as kinase inhibitors. Methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases are also described. Described herein are inhibitors of Bruton's tyrosine kinase (Btk). Also described herein are irreversible inhibitors of Btk. Also described herein are reversible inhibitors of Btk. Further described are irreversible inhibitors ofBtk that form a covalent bond with a cysteine residue on Btk. Further described herein are irreversible inhibitors of other tyrosine kinases, wherein the other tyrosine kinases share homology with Btk by having a cysteine residue (including a Cys 481 residue) that can form a covalent bond with the irreversible inhibitor (such tyrosine kinases, are referred herein as "Btk tyrosine kinase cysteine homologs").
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Inventors:
CHEN WEI (US)
JIA ZHAOZHONG J (US)
JIA ZHAOZHONG J (US)
Application Number:
PCT/US2015/038947
Publication Date:
March 10, 2016
Filing Date:
July 02, 2015
Export Citation:
Assignee:
PHARMACYCLICS LLC (US)
International Classes:
A61K31/4166
Domestic Patent References:
| WO2014082598A1 | 2014-06-05 |
Foreign References:
| US20030100768A1 | 2003-05-29 |
Other References:
HAHM ET AL.: "An Efficient Synthesis of Enantiomerically Pure Functionalized Imidazolidin-2-ones from Chiral Aziridines: Supplementary Information.", THE ROYAL SCIENCE OF CHEMISTRY, 2005, Retrieved from the Internet [retrieved on 20150902]
Attorney, Agent or Firm:
JACKSON, David, A. (25 East Spring Valley Avenue - Suite 160Maywood, NJ, US)
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