Title:
JAK1/JAK2/TYK2 INHIBITORS FOR TOPICAL TREATMENT OF DERMATOLOGICAL DISEASES
Document Type and Number:
WIPO Patent Application WO/2024/041397
Kind Code:
A1
Abstract:
Provided 4-pyrazolyl-N-heteroarylpyrimidin-2-amine compounds as potent TYK2/JAK1/JAK2 inhibitors with low systemic exposures when applied topically. Thus, these compounds, and compositions are useful as topical treatment of dermatological disorders related to JAK1/JAK2/TYK2 such as atopic dermatitis, psoriasis, hives, alopecia areata, vitiligo, hidradenitis suppurativa, hand eczema, necrobiosis lipoidica, non-sclerotic cutaneous chronic graft-versus-host disease, hand dermatitis, or Lichen Planus.
Inventors:
LIANG CONGXIN (CN)
LI SHUANGJIANG (CN)
TANG XIAOJING (CN)
HUANG JUNMIN (US)
LI SHUANGJIANG (CN)
TANG XIAOJING (CN)
HUANG JUNMIN (US)
Application Number:
PCT/CN2023/112361
Publication Date:
February 29, 2024
Filing Date:
August 10, 2023
Export Citation:
Assignee:
HANGZHOU HIGHLIGHTLL PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/14; A61K31/506; A61P35/00; C07D413/14
Domestic Patent References:
| WO2023060202A1 | 2023-04-13 | |||
| WO2014111037A1 | 2014-07-24 | |||
| WO2021078021A1 | 2021-04-29 |
Foreign References:
| CN110862380A | 2020-03-06 | |||
| CN101910152A | 2010-12-08 | |||
| CN114181199A | 2022-03-15 | |||
| CN103298794A | 2013-09-11 | |||
| CN113227074A | 2021-08-06 |
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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