Title:
INHIBITORS OF TYPE 5 AND TYPE 3 17 beta -HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE
Document Type and Number:
WIPO Patent Application WO1999046279
Kind Code:
A3
Abstract:
Novel methods of medical treatment and/or inhibition of development of diseases are disclosed for diseases that are sensitive to androgenic or estrogenic activity. The treatments utilize inhibitors of type 5 and/or type 3 17 beta -hydroxysteroid dehydrogenase. Novel inhibitors of type 5 17 beta -hydroxysteroid dehydrogenase are also disclosed, as are novel inhibitors of type 3 17 beta -hydroxysteroid dehydrogenase.
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Inventors:
LABRIE FERNAND
BELANGER ALAIN
GAUTHIER SYLVAIN
LUU-THE VAN
MERAND YVES
POIRIER DONALD
PROVENCHER LOUIS
SINGH SHANKAR MOHAN
BELANGER ALAIN
GAUTHIER SYLVAIN
LUU-THE VAN
MERAND YVES
POIRIER DONALD
PROVENCHER LOUIS
SINGH SHANKAR MOHAN
Application Number:
PCT/CA1999/000205
Publication Date:
February 22, 2001
Filing Date:
March 10, 1999
Export Citation:
Assignee:
ENDORECH INC (CA)
International Classes:
A61K31/56; A61K31/566; A61K31/5685; A61K31/57; A61K31/575; A61K31/585; A61K45/06; A61P5/28; A61P13/08; A61P15/00; A61P17/08; A61P17/10; A61P17/14; A61P35/00; A61P43/00; C07J1/00; C07J5/00; C07J9/00; C07J21/00; C07J41/00; C07J63/00; (IPC1-7): A61K31/00; A61K31/57; A61K31/575; A61K31/565; A61K31/585; A61K31/22; A61K31/56; A61K45/06
Domestic Patent References:
| WO1990010462A1 | 1990-09-20 | |||
| WO1996015794A1 | 1996-05-30 | |||
| WO1986001402A1 | 1986-03-13 | |||
| WO1997011162A1 | 1997-03-27 |
Foreign References:
| BE898057A | 1984-02-15 | |||
| US3917657A | 1975-11-04 | |||
| GB2102287A | 1983-02-02 | |||
| US4684635A | 1987-08-04 | |||
| GB2018591A | 1979-10-24 | |||
| DE2059338A1 | 1972-06-15 | |||
| GB870286A | 1961-06-14 | |||
| FR1405214A | 1965-07-09 |
Other References:
J.E.F. REYNOLDS: "Martindale, The Extra Pharmacopoeia", 1996, ROYAL PHARMACEUTICAL SOCIETY, LONDON, XP002114852
CHEMICAL ABSTRACTS, vol. 130, Columbus, Ohio, US; abstract no. 332443, UMEDA, HIROSHI ET AL: "Elimination of luteinizing hormone-releasing hormone-induced flare reaction by lead-in and combination therapies with chlormadinone acetate in patients with advanced prostate carcinoma - comparison with flutamide treatment -" XP002114853
COUTINHO, E. M. ET AL: "Clinical management of leiomyomas with medroxyprogesterone acetate", INT. CONGR., SYMP. SEMIN. SER. (1995), 11(PROGRESS IN THE MANAGEMENT OF ENDOMETRIOSIS), 421-5, XP002114848
WEST, CHRISTINE P. ET AL: "Potential role for medroxyprogesterone acetate as an adjunct to goserelin (Zoladex) in the medical management of uterine fibroids", HUM. REPROD. (1992), 7(3), 328-32, XP002114849
CHEMICAL ABSTRACTS, vol. 108, Columbus, Ohio, US; abstract no. 16367, MACHIDA, TOYOHEI ET AL: "Hormone therapy for male genital cancer (prostatic cancer)" XP002114854
CHEMICAL ABSTRACTS, vol. 103, Columbus, Ohio, US; abstract no. 27291, SHISEIDO CO., LTD., JAPAN: "Skin lotion containing chlormadinone acetate for acne treatment" XP002114855
DATABASE WPI Section Ch Week 8533, Derwent World Patents Index; Class B01, AN 85-200303, XP002114857
BIERICH, JURGEN R.: "Precocious and retarded puberty", SYMP. DEUT. GES. ENDOKRINOL. (1970), 16, 183-94, XP002114850
CHEMICAL ABSTRACTS, vol. 116, Columbus, Ohio, US; abstract no. 99327, SUDO, KATSUICHI ET AL: "Neovascularization inhibitors containing steroid 17.beta.-carboxylic acid defivatives" XP002114856
R. WIECHERT ET AL.: "The progestational efficacy of 1-methyl and 1,2alpha-methylene steroids", ARZNEIMITTEL-FORSCH., vol. 15, no. 3, 1965, pages 244 - 246, XP002114851
LUU-THE V ET AL: "CHARACTERISTICS OF HUMAN TYPES 1, 2 AND 3 17BETA-HYDROXYSTEROID DEHYDROGENASE ACTIVITIES: OXIDATION/REDUCTION AND INHIBITION", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 55, no. 5/06, 1 January 1995 (1995-01-01), pages 581 - 587, XP000196678, ISSN: 0960-0760
CHEMICAL ABSTRACTS, vol. 130, Columbus, Ohio, US; abstract no. 332443, UMEDA, HIROSHI ET AL: "Elimination of luteinizing hormone-releasing hormone-induced flare reaction by lead-in and combination therapies with chlormadinone acetate in patients with advanced prostate carcinoma - comparison with flutamide treatment -" XP002114853
COUTINHO, E. M. ET AL: "Clinical management of leiomyomas with medroxyprogesterone acetate", INT. CONGR., SYMP. SEMIN. SER. (1995), 11(PROGRESS IN THE MANAGEMENT OF ENDOMETRIOSIS), 421-5, XP002114848
WEST, CHRISTINE P. ET AL: "Potential role for medroxyprogesterone acetate as an adjunct to goserelin (Zoladex) in the medical management of uterine fibroids", HUM. REPROD. (1992), 7(3), 328-32, XP002114849
CHEMICAL ABSTRACTS, vol. 108, Columbus, Ohio, US; abstract no. 16367, MACHIDA, TOYOHEI ET AL: "Hormone therapy for male genital cancer (prostatic cancer)" XP002114854
CHEMICAL ABSTRACTS, vol. 103, Columbus, Ohio, US; abstract no. 27291, SHISEIDO CO., LTD., JAPAN: "Skin lotion containing chlormadinone acetate for acne treatment" XP002114855
DATABASE WPI Section Ch Week 8533, Derwent World Patents Index; Class B01, AN 85-200303, XP002114857
BIERICH, JURGEN R.: "Precocious and retarded puberty", SYMP. DEUT. GES. ENDOKRINOL. (1970), 16, 183-94, XP002114850
CHEMICAL ABSTRACTS, vol. 116, Columbus, Ohio, US; abstract no. 99327, SUDO, KATSUICHI ET AL: "Neovascularization inhibitors containing steroid 17.beta.-carboxylic acid defivatives" XP002114856
R. WIECHERT ET AL.: "The progestational efficacy of 1-methyl and 1,2alpha-methylene steroids", ARZNEIMITTEL-FORSCH., vol. 15, no. 3, 1965, pages 244 - 246, XP002114851
LUU-THE V ET AL: "CHARACTERISTICS OF HUMAN TYPES 1, 2 AND 3 17BETA-HYDROXYSTEROID DEHYDROGENASE ACTIVITIES: OXIDATION/REDUCTION AND INHIBITION", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 55, no. 5/06, 1 January 1995 (1995-01-01), pages 581 - 587, XP000196678, ISSN: 0960-0760
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