Title:
INHIBITORY AGENT FOR MYOCARDIAL CELL DEATH, AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR MYOCARDIAL DISORDERS OR HEART FAILURE
Document Type and Number:
WIPO Patent Application WO/2023/234410
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: an inhibitory agent for myocardial cell death; and a prophylactic or therapeutic agent for myocardial disorders or heart failure. The problem is solved by an inhibitory agent for myocardial cell death or a prophylactic or therapeutic agent for myocardial disorders or heart failure, the agent containing at least one component selected from the group consisting of a TAOK1 function inhibitor and a TAOK1 expression inhibitor.
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Inventors:
KITANI TOMOYA (JP)
MATOBA SATOAKI (JP)
MATOBA SATOAKI (JP)
Application Number:
PCT/JP2023/020619
Publication Date:
December 07, 2023
Filing Date:
June 02, 2023
Export Citation:
Assignee:
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
International Classes:
A61K45/00; A61K31/7088; A61K38/02; A61K39/395; A61K48/00; A61P9/00; A61P9/04; A61P39/00; A61P43/00; C12Q1/48; C12Q1/68; G01N33/15; G01N33/50; G01N33/53
Foreign References:
| JP2007527412A | 2007-09-27 |
Other References:
CHEN FRANK C., BROZOVICH FRANK V.: "Gene Expression Profiles of Vascular Smooth Muscle Show Differential Expression of Mitogen-Activated Protein Kinase Pathways during Captopril Therapy of Heart Failure", JOURNAL OF VASCULAR RESEARCH., KARGER, BASEL., CH, vol. 45, no. 5, 1 January 2008 (2008-01-01), CH , pages 445 - 454, XP009551398, ISSN: 1018-1172, DOI: 10.1159/000126735
ZHANG LITING, CHEN DAN, PENG MIN, MA HONGBO: "Effects of Yixintai Pills on Myocardial Cell Apoptosis in Rats With Adriamycin-Induced Heart Failure", THE HEART SURGERY FORUM, CHARLOTTESVILLE : FORUM MULTIMEDIA PUBL., US, vol. 23, no. 2, US , pages E234 - E238, XP093116296, ISSN: 1098-3511, DOI: 10.1532/hsf.2941
SAPP VALERIE, AGUIRRE AITOR, MAINKAR GAYATRI, DING JEFFREY, ADLER ERIC, LIAO RONGLIH, SHARMA SONIA, JAIN MOHIT: "Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 11, no. 1, 1 December 2021 (2021-12-01), US , pages 13866 - 9, XP055966123, ISSN: 2045-2322, DOI: 10.1038/s41598-021-92988-1
ZHANG LITING, CHEN DAN, PENG MIN, MA HONGBO: "Effects of Yixintai Pills on Myocardial Cell Apoptosis in Rats With Adriamycin-Induced Heart Failure", THE HEART SURGERY FORUM, CHARLOTTESVILLE : FORUM MULTIMEDIA PUBL., US, vol. 23, no. 2, US , pages E234 - E238, XP093116296, ISSN: 1098-3511, DOI: 10.1532/hsf.2941
SAPP VALERIE, AGUIRRE AITOR, MAINKAR GAYATRI, DING JEFFREY, ADLER ERIC, LIAO RONGLIH, SHARMA SONIA, JAIN MOHIT: "Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 11, no. 1, 1 December 2021 (2021-12-01), US , pages 13866 - 9, XP055966123, ISSN: 2045-2322, DOI: 10.1038/s41598-021-92988-1
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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