Title:
INJECTABLE POLYHYDROXYALKANOATE MICROSPHERES AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/061201
Kind Code:
A1
Abstract:
A preparation method for injectable polyhydroxyalkanoate (PHA) microspheres. The preparation method comprises: a) dissolving a PHA material in an organic solvent to obtain an oil phase; b) dissolving hyaluronic acid in water to obtain a water phase; and c) dropwise adding the oil phase into the water phase under stirring conditions, continuously stirring same to volatilize the organic solvent after the addition is finished, and then carrying out solid-liquid separation and drying same to obtain PHA microspheres, wherein step a) and step b) are not limited in sequence. The PHA microspheres obtained by means of the method can be rapidly dispersed in water, the microspheres are complete in morphology and independent from one another, and are free of agglomeration, such that a needle head is prevented from being blocked, and subsequent injection thereof as a filler is facilitated.
Inventors:
WEI DAIXU (CN)
LI TENG (CN)
ZHANG HAOQIAN (CN)
TAN CHANG (CN)
LI TENG (CN)
ZHANG HAOQIAN (CN)
TAN CHANG (CN)
Application Number:
PCT/CN2022/121527
Publication Date:
April 20, 2023
Filing Date:
September 27, 2022
Export Citation:
Assignee:
BEIJING BLUEPHA MICROBIOLOGY TECH CO LTD (CN)
International Classes:
A61L27/18; A61L27/20; A61L27/26; A61L27/50; B01J3/04
Foreign References:
| CN113616604A | 2021-11-09 | |||
| RU2692768C1 | 2019-06-27 | |||
| CN114588310A | 2022-06-07 | |||
| CN114788895A | 2022-07-26 | |||
| CN113230451A | 2021-08-10 | |||
| CN104667346A | 2015-06-03 | |||
| CN110200936A | 2019-09-06 |
Other References:
ZHANG JUNYU; SHISHATSKAYA EKATERINA I.; VOLOVA TATIANA G.; DA SILVA LUIZIANA FERREIRA; CHEN GUO-QIANG: "Polyhydroxyalkanoates (PHA) for therapeutic applications", MATERIALS SCIENCE AND ENGINEERING C, ELSEVIER SCIENCE S.A., CH, vol. 86, 5 January 2018 (2018-01-05), CH , pages 144 - 150, XP085358296, ISSN: 0928-4931, DOI: 10.1016/j.msec.2017.12.035
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
Download PDF: