Title:
INSOLUBLE TRANSDERMAL MICRONEEDLE PATCH, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/040568
Kind Code:
A1
Abstract:
An insoluble transdermal microneedle patch, comprising: microneedles, the microneedles each comprising a base and a needlepoint located on the base, and the microneedle being mainly composed of cross-linked sodium alginate; and a backing, which is bonded to the base, part of the backing corresponding to the needlepoints being a hollowed-out portion. Further disclosed is a preparation method for the microneedle patch and an application thereof. The microneedle patch may act on the skin for a long time, and when same is used for transdermal drug administration, a drug may enter, by means of swollen pores after microneedles have acted on the skin after absorbing water, the micropores of the skin and be absorbed into the body, thereby increasing the bioavailability of the drug when administered transdermally. After drug administration has ended, the microneedles may be completely removed without increasing the metabolic burden in the body.
Inventors:
GAO YUNHUA (CN)
ZHOU ZEQUAN (CN)
ZHANG SUOHUI (CN)
YANG GUOZHONG (CN)
ZHOU ZEQUAN (CN)
ZHANG SUOHUI (CN)
YANG GUOZHONG (CN)
Application Number:
PCT/CN2022/113262
Publication Date:
March 23, 2023
Filing Date:
August 18, 2022
Export Citation:
Assignee:
TECHNICAL INST PHYSICS & CHEMISTRY CAS (CN)
BEIJING CAS MICRONEEDLE TECH LTD (CN)
BEIJING CAS MICRONEEDLE TECH LTD (CN)
International Classes:
A61K9/00; A61K45/00; A61K47/36; A61M37/00
Foreign References:
| CN113797155A | 2021-12-17 | |||
| CN107412201A | 2017-12-01 | |||
| CN109364366A | 2019-02-22 |
Other References:
WEI CHEN, ET AL.: "Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy", NATURE COMMUNICATIONS, vol. 8, no. 1, 1 December 2017 (2017-12-01), pages 1 - 11, XP055710786, DOI: 10.1038/s41467-017-01764-1
ZHANG, YANG ET AL.: "Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats.", MATERIALS SCIENCE & ENGINEERING C., vol. 85, 15 December 2017 (2017-12-15), XP085415447, ISSN: 0928-4931, DOI: 10.1016/j.msec.2017.12.006
ZHANG, YANG ET AL.: "Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats.", MATERIALS SCIENCE & ENGINEERING C., vol. 85, 15 December 2017 (2017-12-15), XP085415447, ISSN: 0928-4931, DOI: 10.1016/j.msec.2017.12.006
Attorney, Agent or Firm:
BEIJING ZHUOSHENG BAIDA IP AGENT LTD. (CN)
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