Title:
INTRAOCULAR IMPLANTS FOR PREVENTING TRANSPLANT REJECTION IN THE EYE
Document Type and Number:
WIPO Patent Application WO2002043785
Kind Code:
A3
Abstract:
Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a biorodible polymer.
Inventors:
WONG VERNON G (US)
Application Number:
PCT/US2001/044481
Publication Date:
November 21, 2002
Filing Date:
November 28, 2001
Export Citation:
Assignee:
OCULEX PHARM INC (US)
WONG VERNON G (US)
WONG VERNON G (US)
International Classes:
A61F2/00; A61F9/00; A61K9/00; A61K31/573; A61K31/715; A61K31/765; A61K38/00; A61K45/00; A61K45/06; A61K47/38; A61L27/54; A61P27/02; A61P37/06; A61P41/00; A61P43/00; A61F2/02; (IPC1-7): A61L27/54; A61K9/00; A61K31/573; A61K38/13; A61P37/06; A61P27/02
Domestic Patent References:
| WO2000037056A2 | 2000-06-29 |
Other References:
APEL A ET AL: "A subconjunctival degradable implant for cyclosporine delivery in corneal transplant therapy.", CURRENT EYE RESEARCH. ENGLAND AUG 1995, vol. 14, no. 8, August 1995 (1995-08-01), pages 659 - 667, XP001083691, ISSN: 0271-3683
TAN DONALD T H ET AL: "Randomized clinical trial of a new dexamethasone delivery system (Surodex) for treatment of post-cataract surgery inflammation.", OPHTHALMOLOGY, vol. 106, no. 2, February 1999 (1999-02-01), pages 223 - 231, XP001083687, ISSN: 0161-6420
MORITA YASUSHI ET AL: "Intravitreous delivery of dexamethasone sodium m-sulfobenzoate from poly(DL-lactic acid) implants.", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 21, no. 2, February 1998 (1998-02-01), pages 188 - 190, XP001084085, ISSN: 0918-6158
GOULD L ET AL: "Fifty:fifty poly (DL glycolic acid-lactic acid) copolymer as a drug delivery system for 5-fluorouracil: a histopathological evaluation.", CANADIAN JOURNAL OF OPHTHALMOLOGY. JOURNAL CANADIEN D'OPHTALMOLOGIE. CANADA AUG 1994, vol. 29, no. 4, August 1994 (1994-08-01), pages 168 - 171, XP001083692, ISSN: 0008-4182
DAVIS, P. A. ET AL: "Intraocular implant for controlled 5-fluorouracil release", PROC. INT. SYMP. CONTROLLED RELEASE BIOACT. MATER., 19TH (1992), 339-40. EDITOR(S): KOPECEK, JINDRICH. PUBLISHER: CONTROLLED RELEASE SOC., DEERFIELD, ILL., XP001084532
TAN DONALD T H ET AL: "Randomized clinical trial of a new dexamethasone delivery system (Surodex) for treatment of post-cataract surgery inflammation.", OPHTHALMOLOGY, vol. 106, no. 2, February 1999 (1999-02-01), pages 223 - 231, XP001083687, ISSN: 0161-6420
MORITA YASUSHI ET AL: "Intravitreous delivery of dexamethasone sodium m-sulfobenzoate from poly(DL-lactic acid) implants.", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 21, no. 2, February 1998 (1998-02-01), pages 188 - 190, XP001084085, ISSN: 0918-6158
GOULD L ET AL: "Fifty:fifty poly (DL glycolic acid-lactic acid) copolymer as a drug delivery system for 5-fluorouracil: a histopathological evaluation.", CANADIAN JOURNAL OF OPHTHALMOLOGY. JOURNAL CANADIEN D'OPHTALMOLOGIE. CANADA AUG 1994, vol. 29, no. 4, August 1994 (1994-08-01), pages 168 - 171, XP001083692, ISSN: 0008-4182
DAVIS, P. A. ET AL: "Intraocular implant for controlled 5-fluorouracil release", PROC. INT. SYMP. CONTROLLED RELEASE BIOACT. MATER., 19TH (1992), 339-40. EDITOR(S): KOPECEK, JINDRICH. PUBLISHER: CONTROLLED RELEASE SOC., DEERFIELD, ILL., XP001084532
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