Title:
USES FOR MEDICAL DEVICES HAVING A LUBRICIOUS, NITRIC OXIDE-RELEASING COATING FOR THE THERAPY OF VASCULAR DISORDERS
Document Type and Number:
WIPO Patent Application WO2002043786
Kind Code:
A3
Abstract:
Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or associated with various NO-related conditions. The disclosed methods comprise contacting the vascular tissue of a patient with a medicaldevice coated with a coating comprising nitric oxide associated with and releaseable from a polyurea network formed from the reaction on said medical device of a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidine, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.
Inventors:
TEDESCHI EUGENE (US)
SHAH CHIRAG B (US)
SHAH CHIRAG B (US)
Application Number:
PCT/US2001/043719
Publication Date:
January 30, 2003
Filing Date:
November 20, 2001
Export Citation:
Assignee:
MEDTRONIC AVE INC (US)
TEDESCHI EUGENE (US)
SHAH CHIRAG B (US)
TEDESCHI EUGENE (US)
SHAH CHIRAG B (US)
International Classes:
A61K33/00; A61L27/00; A61L27/34; A61M31/00; A61L27/54; A61L29/00; A61L29/08; A61L29/16; A61L31/00; A61L31/10; A61L31/16; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/16; A61P13/08; A61P31/04; (IPC1-7): A61L27/18; A61L27/54; A61P9/00
Domestic Patent References:
| WO2001085227A2 | 2001-11-15 | |||
| WO2001010344A1 | 2001-02-15 |
Foreign References:
| EP0992252A2 | 2000-04-12 | |||
| US5665077A | 1997-09-09 | |||
| US5356433A | 1994-10-18 | |||
| US5645931A | 1997-07-08 | |||
| US5405919A | 1995-04-11 |
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