Title:
IODINATED TRIGLYCERIDE ANALOGS
Document Type and Number:
WIPO Patent Application WO2003080554
Kind Code:
A3
Abstract:
A compound represented by the following general formula (IA) or a salt thereof: wherein Ar>1< represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar>2< represents an aryl group having at least one iodine atom as a substituent; L>1< AND L>2< independently represent a divalent bridging group of which main chain contains 6 or more carbon atoms; L>3< represents a single bond or a divalent bridging group of which main chain contains 1 to 6 carbon atoms and one oxygen atom; X represents a functional group containing at least one heteroatom, provided that, when L>3< is a single bond, X represents a functional group other than hydroxyl group. The compound can be used as a membrane component of liposomes, and the liposomes can be used as a contrast medium for X-ray radiography.
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Inventors:
TAKAHASHI KAZUNOBU (JP)
KITAGUCHI HIROSHI (JP)
AIKAWA KAZUHIRO (JP)
KITAGUCHI HIROSHI (JP)
AIKAWA KAZUHIRO (JP)
Application Number:
PCT/JP2003/003814
Publication Date:
April 15, 2004
Filing Date:
March 27, 2003
Export Citation:
Assignee:
FUJI PHOTO FILM CO LTD (JP)
TAKAHASHI KAZUNOBU (JP)
KITAGUCHI HIROSHI (JP)
AIKAWA KAZUHIRO (JP)
TAKAHASHI KAZUNOBU (JP)
KITAGUCHI HIROSHI (JP)
AIKAWA KAZUHIRO (JP)
International Classes:
C07D295/14; A61K9/127; A61K49/04; A61K51/00; A61K51/12; C07C69/712; C07C69/734; C07C233/05; C07C275/14; C07C275/50; C07D295/15; C07D295/20; C07F9/09; C07F9/10; C07F9/117; (IPC1-7): C07D265/30; C07C233/11; C07C69/734; A61K51/12; A61K51/04; A61K49/04
Foreign References:
| US6103216A | 2000-08-15 | |||
| US4873075A | 1989-10-10 | |||
| EP0037583A1 | 1981-10-14 |
Other References:
WEICHERT J P ET AL: "POLYIODINATED TRIGLYCERIDE ANALOGS AS POTENTIAL COMPUTED TOMOGRAPHY IMAGING AGENTS FOR THE LIVER", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 38, no. 4, 17 February 1995 (1995-02-17), pages 636 - 646, XP001057012, ISSN: 0022-2623
J. P. WEICHERT ET AL.: "Combined hepatocyte-selective and blood-pool contrast agents for the CT-detection of experimental livre tumors in rabbits.", RADIOLOGY, vol. 216, no. 3, 2000, pages 865 - 871, XP002244766
K. BHARDWAJ ET AL.: "Identification, purification and characterization of a thermally stable lipse from rice bran. a new member of the (phospho)lipase family.", PLANT PHYSIOLOGY, vol. 127, no. 4, 2001, pages 1728 - 1738, XP002244767
J. P. WEICHERT ET AL.: "Potential tumor- or organ-imaging agents.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 12, 1986, pages 2457 - 2465, XP002244768
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1986, J. P. WEICHERT ET AL.: "Polyiodinated triglyceride analogs as potential hepatic imaging agents", XP002244769, Database accession no. 1986:530036
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2000, J. P. WEICHERT ET AL.: "Polyiodinated triglyceride lipid emulsions for use as hepatoselective contrast agents in CT: effects of physicochemical properties on biodistribution and imaging profiles", XP002244770, Database accession no. 2000:205019
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1992, SCHWENDNER S.W. ET AL.: "Potential organ or tumor imaging agents", XP002244771, Database accession no. 1992:587410
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1993, FF KNAPP ET AL.: "Site-specific stable radioiodination of 1,2-Pal-3-IPPA: an agent for the potential clinical evaluation of pancreatic insufficiency by urine analysis", XP002244772, Database accession no. 93286735
M-L ALCARAZ ET AL.: "Synthesis and properties of photoactivatable phospholipid derivatives designed to probe the membrane-associate domains of proteins", JOURNAL OF ORGANIC CHEMISTRY, vol. 61, 1996, pages 192 - 201, XP002250373
B. CORSICO ET AL.: "Evidence for a central apolipoprotein A-I domain loosely bound to lipids in discoidal lipoproteins that us capable of penetrating the bilayer of phospholipid vesicles", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 20, 2001, pages 16978 - 16985, XP002250374
Y. OGAWA ET AL.: "Regioselective photolabeling of glycoprotein A in membranes", CHEM. EUR. JOURNAL, vol. 8, no. 8, 2002, pages 1843 - 1849, XP002250375
J. P. WEICHERT ET AL.: "Combined hepatocyte-selective and blood-pool contrast agents for the CT-detection of experimental livre tumors in rabbits.", RADIOLOGY, vol. 216, no. 3, 2000, pages 865 - 871, XP002244766
K. BHARDWAJ ET AL.: "Identification, purification and characterization of a thermally stable lipse from rice bran. a new member of the (phospho)lipase family.", PLANT PHYSIOLOGY, vol. 127, no. 4, 2001, pages 1728 - 1738, XP002244767
J. P. WEICHERT ET AL.: "Potential tumor- or organ-imaging agents.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 12, 1986, pages 2457 - 2465, XP002244768
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1986, J. P. WEICHERT ET AL.: "Polyiodinated triglyceride analogs as potential hepatic imaging agents", XP002244769, Database accession no. 1986:530036
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2000, J. P. WEICHERT ET AL.: "Polyiodinated triglyceride lipid emulsions for use as hepatoselective contrast agents in CT: effects of physicochemical properties on biodistribution and imaging profiles", XP002244770, Database accession no. 2000:205019
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1992, SCHWENDNER S.W. ET AL.: "Potential organ or tumor imaging agents", XP002244771, Database accession no. 1992:587410
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1993, FF KNAPP ET AL.: "Site-specific stable radioiodination of 1,2-Pal-3-IPPA: an agent for the potential clinical evaluation of pancreatic insufficiency by urine analysis", XP002244772, Database accession no. 93286735
M-L ALCARAZ ET AL.: "Synthesis and properties of photoactivatable phospholipid derivatives designed to probe the membrane-associate domains of proteins", JOURNAL OF ORGANIC CHEMISTRY, vol. 61, 1996, pages 192 - 201, XP002250373
B. CORSICO ET AL.: "Evidence for a central apolipoprotein A-I domain loosely bound to lipids in discoidal lipoproteins that us capable of penetrating the bilayer of phospholipid vesicles", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 20, 2001, pages 16978 - 16985, XP002250374
Y. OGAWA ET AL.: "Regioselective photolabeling of glycoprotein A in membranes", CHEM. EUR. JOURNAL, vol. 8, no. 8, 2002, pages 1843 - 1849, XP002250375
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