Title:
IONIZABLE LIPID CONTAINING BIODEGRADABLE DISULFIDE BOND AND LIPID NANOPARTICLES COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2023/136688
Kind Code:
A1
Abstract:
The present invention relates to a novel ionizable lipid containing a biodegradable disulfide bond. The ionizable lipid containing a disulfide bond, according to the present invention, stably delivers an anionic drug when prepared into lipid nanoparticles and exhibits an excellent effect, in particular, in delivering nucleic acids, and thus can be effectively used in related technical fields such as lipid nanoparticle-mediated gene therapy.
Inventors:
KIM KYUNG JIN (KR)
YANG JOO SUNG (KR)
CHOI KANG HYUN (KR)
KIM UK-IL (KR)
LEE JOO YOUNG (KR)
LEE HYUK JIN (KR)
KIM MIN JEONG (KR)
JEONG YEA HEE (KR)
LEE YE JI (KR)
YANG JOO SUNG (KR)
CHOI KANG HYUN (KR)
KIM UK-IL (KR)
LEE JOO YOUNG (KR)
LEE HYUK JIN (KR)
KIM MIN JEONG (KR)
JEONG YEA HEE (KR)
LEE YE JI (KR)
Application Number:
PCT/KR2023/000738
Publication Date:
July 20, 2023
Filing Date:
January 16, 2023
Export Citation:
Assignee:
ST PHARM CO LTD (KR)
International Classes:
A61K9/51; A61K9/127; A61K47/20; A61K47/22; A61K48/00; C07C319/22; C07C323/25; C07D295/04
Domestic Patent References:
| WO2019036028A1 | 2019-02-21 | |||
| WO2014028487A1 | 2014-02-20 |
Foreign References:
| US20170204076A1 | 2017-07-20 | |||
| CN113402404A | 2021-09-17 | |||
| US20200368173A1 | 2020-11-26 |
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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