Title:
IONIZABLE LIPID CONTAINING BIODEGRADABLE ESTER BOND AND LIPID NANOPARTICLES COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2023/136689
Kind Code:
A1
Abstract:
The present invention relates to a novel ionizable lipid containing a biodegradable ester bond. The ionizable lipid containing an ester bond, according to the present invention, stably delivers an anionic drug when prepared into lipid nanoparticles, and exhibits an excellent effect, in particular, in delivering nucleic acids, and thus can be effectively used in related technical fields such as lipid nanoparticle-mediated gene therapy.
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Inventors:
KIM KYUNG JIN (KR)
YANG JOO SUNG (KR)
CHOI KANG HYUN (KR)
KIM UK-IL (KR)
LEE JOO YOUNG (KR)
LEE HYUK JIN (KR)
KIM MIN JEONG (KR)
JEONG YEA HEE (KR)
LEE YE JI (KR)
YANG JOO SUNG (KR)
CHOI KANG HYUN (KR)
KIM UK-IL (KR)
LEE JOO YOUNG (KR)
LEE HYUK JIN (KR)
KIM MIN JEONG (KR)
JEONG YEA HEE (KR)
LEE YE JI (KR)
Application Number:
PCT/KR2023/000742
Publication Date:
July 20, 2023
Filing Date:
January 16, 2023
Export Citation:
Assignee:
ST PHARM CO LTD (KR)
International Classes:
A61K9/51; A61K9/127; A61K47/18; A61K47/22; A61K48/00; C07C219/20; C07D295/04
Domestic Patent References:
| WO2018232120A1 | 2018-12-20 |
Foreign References:
| US20140308304A1 | 2014-10-16 | |||
| US20210107861A1 | 2021-04-15 | |||
| US20200163878A1 | 2020-05-28 |
Other References:
WHITEHEAD KATHRYN A., DORKIN J. ROBERT, VEGAS ARTURO J., CHANG PHILIP H., VEISEH OMID, MATTHEWS JONATHAN, FENTON OWEN S., ZHANG YU: "Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity", NATURE COMMUNICATIONS, vol. 5, no. 1, 27 June 2014 (2014-06-27), XP093028018, DOI: 10.1038/ncomms5277
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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