Title:
ISOINDOLINONE DERIVATIVE HAVING ARYLCYCLOALKYLAMIDE STRUCTURE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/101763
Kind Code:
A1
Abstract:
The present invention relates to an isoindolinone derivative compound having a glutarimide mother nucleus, and an application thereof, and more specifically, to an isoindolinone derivative compound in which a glutarimide mother nucleus is substituted with phenylcyclopropane having a thalidomide analog structure. The compound of chemical formula 1 according to the present invention specifically binds to the CRBN protein and is involved in functions thereof. Thus, the compound of the present invention may be beneficially used in the prevention or treatment of leprosy, chronic graft versus host disease, inflammatory diseases, or cancer caused by actions of the CRBN protein.
Inventors:
HWANG JONG YEON (KR)
LEE SOON IM (KR)
KOO JAE KYUNG (KR)
CHOE SEONG CHOON (KR)
CHO SUNG YUN (KR)
HA JAE DU (KR)
KIM PIL HO (KR)
KIM HYUN JIN (KR)
CHO YONG HEE (KR)
AKSHAY DIW (KR)
LEE SOON IM (KR)
KOO JAE KYUNG (KR)
CHOE SEONG CHOON (KR)
CHO SUNG YUN (KR)
HA JAE DU (KR)
KIM PIL HO (KR)
KIM HYUN JIN (KR)
CHO YONG HEE (KR)
AKSHAY DIW (KR)
Application Number:
PCT/KR2023/017237
Publication Date:
May 16, 2024
Filing Date:
November 01, 2023
Export Citation:
Assignee:
ONCORD BIO INC (KR)
KOREA RES INST CHEMICAL TECH (KR)
KOREA RES INST CHEMICAL TECH (KR)
International Classes:
C07D401/04; A61K31/454; A61P29/00; A61P35/00; A61P37/06
Domestic Patent References:
| WO2008027542A2 | 2008-03-06 | |||
| WO2002059106A1 | 2002-08-01 |
Foreign References:
| KR20110019761A | 2011-02-28 | |||
| KR101696938B1 | 2017-01-16 | |||
| CN114835680A | 2022-08-02 |
Attorney, Agent or Firm:
GHONG-GAN INTERNATIONAL PATENT LAW FIRM (KR)
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