Title:
ISOINDOLINONE DERIVATIVE HAVING QUINOLINE AMIDE STRUCTURE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/101764
Kind Code:
A1
Abstract:
The present invention relates to: an isoindolinone derivative compound having a glutarimide mother nucleus in which quinoline is substituted; and application thereof, and, more specifically, to an isoindolinone derivative compound having a glutarimide mother nucleus, in which quinoline is substituted, with a thalidomide analog structure. A compound of chemical formula 1, according to the present invention, specifically binds to a CRBN protein and is involved in functions thereof. Therefore, the compound of the present invention can be effectively used in the prevention or treatment of leprosy, chronic graft versus host disease, inflammatory diseases or cancer, which are caused by activity of the CRBN protein.
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Inventors:
HWANG JONG YEON (KR)
LEE SOON IM (KR)
KOO JAE KYUNG (KR)
CHOE SEONG CHOON (KR)
CHO SUNG YUN (KR)
HA JAE DU (KR)
KIM PIL HO (KR)
KIM HYUN JIN (KR)
CHO YONG HEE (KR)
AKSHAY DIW (KR)
LEE SOON IM (KR)
KOO JAE KYUNG (KR)
CHOE SEONG CHOON (KR)
CHO SUNG YUN (KR)
HA JAE DU (KR)
KIM PIL HO (KR)
KIM HYUN JIN (KR)
CHO YONG HEE (KR)
AKSHAY DIW (KR)
Application Number:
PCT/KR2023/017239
Publication Date:
May 16, 2024
Filing Date:
November 01, 2023
Export Citation:
Assignee:
ONCORD BIO INC (KR)
KOREA RES INST CHEMICAL TECH (KR)
KOREA RES INST CHEMICAL TECH (KR)
International Classes:
C07D401/14; A61K31/4709; A61P29/00; A61P35/00; A61P37/06
Attorney, Agent or Firm:
GHONG-GAN INTERNATIONAL PATENT LAW FIRM (KR)
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