JAVELINIZATION OF PROTEIN ANTIGENS TO HEAT SHOCK PROTEINS

Title:

JAVELINIZATION OF PROTEIN ANTIGENS TO HEAT SHOCK PROTEINS

Document Type and Number:

WIPO Patent Application WO2001079259

Kind Code:

A8

Abstract:

The present invention relates to antigenic complexes, wherein an antigenic complex comprises a peptide or protein containing a plurality of epitopes non-covalently joined to a heat shock protein via a molecular tether referred to as a "javelin". Such complexes do not require that each epitope Be defined, and may, in certain embodiments, elicit both antibody and cell-mediated immune reactions. The complexes of the invention may be used to induce therapeutic immune responses directed toward the treatment or prevention of infectious diseases and malignancies.

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Inventors:

ROTHMAN JAMES E (US)
MAYHEW MARK (US)
HOE MEE (US)

Application Number:

PCT/US2001/012567

Publication Date:

December 20, 2001

Filing Date:

April 17, 2001

Export Citation:

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Assignee:

ROTHMAN JAMES E (US)
MAYHEW MARK (US)
HOE MEE (US)

International Classes:

A61K39/00; A61K39/295; A61P31/04; A61P31/12; A61P35/00; C12N15/09; A61P37/00; A61P37/04; C07K14/47; C07K19/00; (IPC1-7): C07K1/00; C07K1/04; C07K1/10; C07K14/76; C07K19/00

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