Title:
KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005123672
Kind Code:
A3
Abstract:
The invention relates to compounds having one of the below formulae that may be used to inhibit kinases as well as compositions of matter and kits comprising these compounds, and methodsusing the compounds.
Inventors:
BRESSI JEROME C (US)
GANGLOFF ANTHONY R (US)
HOSFIELD DAVID J (US)
JENNINGS ANDREW JOHN (US)
PARASELLI BHEEMA R (US)
STAFFORD JEFFREY ALAN (US)
GANGLOFF ANTHONY R (US)
HOSFIELD DAVID J (US)
JENNINGS ANDREW JOHN (US)
PARASELLI BHEEMA R (US)
STAFFORD JEFFREY ALAN (US)
Application Number:
PCT/US2005/020890
Publication Date:
March 02, 2006
Filing Date:
June 13, 2005
Export Citation:
Assignee:
TAKEDA SAN DIEGO INC (US)
BRESSI JEROME C (US)
GANGLOFF ANTHONY R (US)
HOSFIELD DAVID J (US)
JENNINGS ANDREW JOHN (US)
PARASELLI BHEEMA R (US)
STAFFORD JEFFREY ALAN (US)
BRESSI JEROME C (US)
GANGLOFF ANTHONY R (US)
HOSFIELD DAVID J (US)
JENNINGS ANDREW JOHN (US)
PARASELLI BHEEMA R (US)
STAFFORD JEFFREY ALAN (US)
International Classes:
C07D209/00; C07D401/04; C07D403/04; C07D471/04; C07D513/04; (IPC1-7): C07D401/04; A61K31/429; A61K31/437; A61K31/4375; A61K31/4725; A61K31/506; C07D403/04; C07D471/04; C07D513/04
Domestic Patent References:
| WO2002083654A1 | 2002-10-24 | |||
| WO2005105788A1 | 2005-11-10 |
Other References:
SUN L ET AL: "Identification of substituted 3-(4,5,6,7-tetrahydro-1H-indol-2-yl)met hylene)-1,3-dihydroindol-2-ones asgrowth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1 and PDGF-Rbeta tyroine kinases", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, 23 June 2000 (2000-06-23), pages 2655 - 2663, XP002222716, ISSN: 0022-2623
LI SUN ET AL: "Synthesis and biological evaluation of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases", JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON, US, vol. 41, no. 14, 1998, pages 2588 - 2603, XP002184621
LI SUN ET AL: "Synthesis and biological evaluation of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases", JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON, US, vol. 41, no. 14, 1998, pages 2588 - 2603, XP002184621
Download PDF: