Title:
PYRROLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/123671
Kind Code:
A1
Abstract:
A pyrrole derivative represented by the general formula (1): (wherein R1 represents hydrogen or C1-4 alkyl; R2 represents C1-10 alkyl, C3-10 cycloalkyl, methylenedioxyphenyl, 1,2-ethylenedioxyphenyl, 1,3-propylenedioxyphenyl, etc.; R3 and R4 are the same or different and each represents hydrogen, halogeno, C1-6 alkyl, or C1-6 alkoxy; and R5 represents hydrogen, halogeno, nitro, amino, hydroxy, C1-6 alkyl, C1-6 alkoxy, etc.) or a pharmaceutically acceptable salt of the derivative. The compounds inhibit the enzymatic activity of LcK, which participates in the abnormal activation of immunocompetent cells, and are useful for rejection reactions in organ transplantation or immune/allergic diseases such as atopic dermatitis and asthma.
Inventors:
UMEMIYA HIROKI (JP)
TAKAYAMA TETSUO (JP)
AMADA HIDEAKI (JP)
SHIOZAWA FUMIYASU (JP)
SATO MASAKAZU (JP)
YABUUCHI TETSUYA (JP)
KATAKAI HIRONORI (JP)
TAKAYAMA TETSUO (JP)
AMADA HIDEAKI (JP)
SHIOZAWA FUMIYASU (JP)
SATO MASAKAZU (JP)
YABUUCHI TETSUYA (JP)
KATAKAI HIRONORI (JP)
Application Number:
PCT/JP2005/011343
Publication Date:
December 29, 2005
Filing Date:
June 21, 2005
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
UMEMIYA HIROKI (JP)
TAKAYAMA TETSUO (JP)
AMADA HIDEAKI (JP)
SHIOZAWA FUMIYASU (JP)
SATO MASAKAZU (JP)
YABUUCHI TETSUYA (JP)
KATAKAI HIRONORI (JP)
UMEMIYA HIROKI (JP)
TAKAYAMA TETSUO (JP)
AMADA HIDEAKI (JP)
SHIOZAWA FUMIYASU (JP)
SATO MASAKAZU (JP)
YABUUCHI TETSUYA (JP)
KATAKAI HIRONORI (JP)
International Classes:
A61K31/40; A61K31/4025; A61K31/422; A61K31/435; A61K31/439; A61K31/4439; A61K31/454; A61K31/496; A61K31/506; A61K31/5377; A61K31/55; A61P11/06; A61P17/04; A61P37/00; A61P37/06; A61P43/00; C07D207/34; C07D401/12; C07D403/12; C07D405/06; C07D409/06; C07D413/06; C07D453/02; C07D455/02; (IPC1-7): C07D207/34; A61K31/40; A61K31/4025; A61K31/422; A61K31/435; A61K31/439; A61K31/4439; A61K31/454; A61K31/496; A61K31/506; A61K31/5377; A61K31/55; A61P11/06; A61P17/04; A61P37/00; A61P37/06; A61P43/00; C07D401/12; C07D403/12; C07D405/06; C07D409/06; C07D413/06; C07D453/02; C07D455/02
Foreign References:
| JPH11511755A | 1999-10-12 |
Other References:
CAMPAIGNE E. ET AL: "Synthesis of some 1-methyl-3-alkoxy-5-arylpirrolecarboxylic acids and derivatives.", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 12, no. 1, 1975, pages 67 - 74, XP002991365
Attorney, Agent or Firm:
Satori, Soichi c/o TAISHO PHARMACEUTICAL CO. (LTD. INTELLECTUAL PROPERTY DIVISION 24-1,
Takada 3-chom, Toshima-ku Tokyo 33, JP)
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