Title:
LIGANDS FOR TGF-BETA BINDING PROTEINS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2004082608
Kind Code:
A3
Abstract:
Compositions and methods are provided that relate to the unexpected specific association of (i) the TGF-beta binding protein sclerostin with the BMP antagonist protein chordin to form a complex, and of (ii) the TGF-beta binding protein sclerostin with the BMP antagonist protein noggin to form a complex, either of which complex is incapable of binding to a TGF-beta superfamily member such as a BMP. The invention provides isolated complexes for use in screening assays to identify agents that modulate bone mineralization, and offers other related advantages.
Inventors:
WINKLER DAVID G (US)
LATHAM JOHN (US)
SKONIER JOHN (US)
SHPEKTOR DIANA (US)
HAYES TRENTON (US)
GEOGHEGAN JAMES (US)
LATHAM JOHN (US)
SKONIER JOHN (US)
SHPEKTOR DIANA (US)
HAYES TRENTON (US)
GEOGHEGAN JAMES (US)
Application Number:
PCT/US2004/007565
Publication Date:
January 20, 2005
Filing Date:
March 12, 2004
Export Citation:
Assignee:
CELLTECH R & D INC (US)
WINKLER DAVID G (US)
LATHAM JOHN (US)
SKONIER JOHN (US)
SHPEKTOR DIANA (US)
HAYES TRENTON (US)
GEOGHEGAN JAMES (US)
WINKLER DAVID G (US)
LATHAM JOHN (US)
SKONIER JOHN (US)
SHPEKTOR DIANA (US)
HAYES TRENTON (US)
GEOGHEGAN JAMES (US)
International Classes:
A61K38/18; A61P19/00; C07K14/475; C07K14/51; C07K14/705; G01N33/53; G01N33/74; A61K; (IPC1-7): A61K38/18; G01N33/53; A61P19/00
Domestic Patent References:
| WO2001064885A1 | 2001-09-07 | |||
| WO1999015556A1 | 1999-04-01 | |||
| WO1999003996A1 | 1999-01-28 | |||
| WO1998021335A1 | 1998-05-22 |
Foreign References:
| US6489445B1 | 2002-12-03 |
Other References:
BALEMANS W ET AL: "INCREASED BONE DENSITY IN SCLEROSTEOSIS IS DUE TO THE DEFICIENCY OFA NOVEL SECRETED PROTEIN (SOST)", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 10, no. 5, 2001, pages 537 - 543, XP001058218, ISSN: 0964-6906
GROPPE J ET AL: "STRUCTURAL BASIS OF BMP SIGNALLING INHIBITION BY THE CYSTINE KNOT PROTEIN NOGGIN", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 420, no. 6916, 12 December 2002 (2002-12-12), pages 636 - 642, XP001159617, ISSN: 0028-0836
GROPPE J ET AL: "STRUCTURAL BASIS OF BMP SIGNALLING INHIBITION BY THE CYSTINE KNOT PROTEIN NOGGIN", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 420, no. 6916, 12 December 2002 (2002-12-12), pages 636 - 642, XP001159617, ISSN: 0028-0836
Download PDF: