Title:
A METHOD OF PREPARING GAS-FILLED POLYMER MATRIX MICROPARTICLES USEFUL FOR DELIVERING DRUG
Document Type and Number:
WIPO Patent Application WO2004082607
Kind Code:
A3
Abstract:
A method is provided to prepare drug containing gas-filled porous microparticles having a polymer matrix interior which are useful for ultrasound mediated targeted delivery of a drug. An oil-in-water suspension is formed, both phases are frozen, then the aqueous and nonaqueous frozen phases are removed by sublimation.
Inventors:
SHORT ROBERT E (US)
OTTOBONI THOMAS B (US)
OTTOBONI THOMAS B (US)
Application Number:
PCT/US2004/007529
Publication Date:
November 25, 2004
Filing Date:
March 10, 2004
Export Citation:
Assignee:
POINT BIOMEDICAL CORP (US)
SHORT ROBERT E (US)
OTTOBONI THOMAS B (US)
SHORT ROBERT E (US)
OTTOBONI THOMAS B (US)
International Classes:
A61K9/50; A61K47/48; (IPC1-7): A61K9/14; A61K9/16
Foreign References:
| US5190766A | 1993-03-02 | |||
| US5580575A | 1996-12-03 | |||
| US5558082A | 1996-09-24 |
Other References:
See also references of EP 1608340A4
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