Title:
LIPID COMPOUND HAVING GLYCEROL SKELETON, LIPID CARRIER BASED ON LIPID COMPOUND, NUCLEIC ACID LIPID NANOPARTICLE COMPOSITION, AND PHARMACEUTICAL PREPARATION
Document Type and Number:
WIPO Patent Application WO/2023/179499
Kind Code:
A1
Abstract:
The present invention relates to the field of gene drug delivery, and particularly to a lipid compound having a glycerol skeleton, a lipid carrier based on the lipid compound, a nucleic acid lipid nanoparticle composition, and a pharmaceutical preparation. A compound having a structure shown in formula (I) in the present invention can be used separately to prepare the lipid carrier or used together with other lipid compounds to prepare the lipid carrier. The lipid carrier shows pH responsiveness, has high encapsulation efficiency for nucleic acid drugs, and is beneficial to improving in vivo delivery efficiency of nucleic acid drugs, and contains a plurality of biodegradable ester bonds and is high in lipid metabolism speed and high in biological safety. Moreover, the lipid carrier can also deliver nucleic acid drugs to organs requiring enrichment, and has a good prospect for application.
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Inventors:
HUANG KE (CN)
NI MINJIE (CN)
LI YINGWEN (CN)
HUANG LONGYUE (CN)
ZHANG HUANYU (CN)
SUN ZHENHUA (CN)
NI MINJIE (CN)
LI YINGWEN (CN)
HUANG LONGYUE (CN)
ZHANG HUANYU (CN)
SUN ZHENHUA (CN)
Application Number:
PCT/CN2023/082289
Publication Date:
September 28, 2023
Filing Date:
March 17, 2023
Export Citation:
Assignee:
SUZHOU CUREMED BIOMEDICAL TECH CO LTD (CN)
International Classes:
C07C229/12; A61K9/127; A61K9/14; A61K31/7088; A61K31/7105; A61K31/713; A61K47/18; A61K47/22; A61K48/00; A61P43/00; C07C233/05; C07C323/52; C07D207/16; C07D211/60; C07D233/56
Foreign References:
| CN110891553A | 2020-03-17 | |||
| CN113999128A | 2022-02-01 | |||
| JP2000281569A | 2000-10-10 | |||
| CN111108203A | 2020-05-05 | |||
| CN113194988A | 2021-07-30 | |||
| US5705188A | 1998-01-06 | |||
| DE4222374A1 | 1994-01-13 |
Other References:
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ZOELLNER, P. ET AL.: "Utility of nicotinoyl derivatives in structural studies on mono- and diacylglycerols by gas chromatography/mass spectrometry. Part 1", ORGANIC MASS SPECTROMETRY, vol. 29, no. 5, 31 May 1994 (1994-05-31), pages 253 - 9, XP055693736, DOI: 10.1002/oms.1210290508
P. ZÖLLNER, E. LORBEER: "Utility of nicotinoyl derivatives in structural studies of mono- and diacylglycerols by gas chromatography/mass spectrometry. Part 2", JOURNAL OF MASS SPECTROMETRY, WILEY CHICHESTER, GB, vol. 30, no. 3, 31 March 1995 (1995-03-31), GB , pages 432 - 437, XP009549006, ISSN: 1076-5174, DOI: 10.1002/jms.1190300306
P. ZÖLLNER, R. SCHMID: "Utility of nicotinoyl derivatives in structural studies of mono- and diacylglycerols by gas chromatography/mass spectrometry. Part 3. Application to acylglycerols with methyl branchings and epoxy and cyclopropyl rings", JOURNAL OF MASS SPECTROMETRY, WILEY CHICHESTER, GB, vol. 31, no. 4, 30 April 1996 (1996-04-30), GB , pages 411 - 17, XP009549008, ISSN: 1076-5174
ZOLLNER, PETER ET AL.: "Structure determination of diacylglycerols as their nicotinoyl derivatives by gas chromatography-mass spectrometry", EUROPEAN MASS SPECTROMETRY, vol. 3, no. 4, 31 December 1997 (1997-12-31), pages 309 - 315, XP009520342, DOI: 10.1255/ejms.9
DEVERRE, J. R . ET AL.: "Synthesis and aqueous organization of 1,3-dipalmitoyl-2-(4-aminobutyryl) glycerol hydrochloride: a diglyceride prodrug", CHEMISTRY AND PHYSICS OF LIPIDS, vol. 59, no. 1, 31 December 1991 (1991-12-31), pages 75 - 81, XP023389940, DOI: 10.1016/0009-3084(91)90065-J
DEVERRE, JEAN ROBERT ET AL.: "In vitro and in vivo evaluation of macrofilaricidal activity of GABA and 1,3-dipalmitoyl-2-(4-aminobutyryl)glycerol hydrochloride: a diglyceride prodrug", PHARMACEUTICA ACTA HELVETIAE, vol. 67, no. 12, 31 December 1992 (1992-12-31), pages 349 - 52, XP008069879
HUBER, W. FREDERICK: "Mono-a-aminoacyl and mono-a-dipeptide triglycerides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 31 December 1955 (1955-12-31), pages 112 - 16, XP002008829, DOI: 10.1021/ja01606a036
ZOELLNER, P. ET AL.: "Utility of nicotinoyl derivatives in structural studies on mono- and diacylglycerols by gas chromatography/mass spectrometry. Part 1", ORGANIC MASS SPECTROMETRY, vol. 29, no. 5, 31 May 1994 (1994-05-31), pages 253 - 9, XP055693736, DOI: 10.1002/oms.1210290508
P. ZÖLLNER, E. LORBEER: "Utility of nicotinoyl derivatives in structural studies of mono- and diacylglycerols by gas chromatography/mass spectrometry. Part 2", JOURNAL OF MASS SPECTROMETRY, WILEY CHICHESTER, GB, vol. 30, no. 3, 31 March 1995 (1995-03-31), GB , pages 432 - 437, XP009549006, ISSN: 1076-5174, DOI: 10.1002/jms.1190300306
P. ZÖLLNER, R. SCHMID: "Utility of nicotinoyl derivatives in structural studies of mono- and diacylglycerols by gas chromatography/mass spectrometry. Part 3. Application to acylglycerols with methyl branchings and epoxy and cyclopropyl rings", JOURNAL OF MASS SPECTROMETRY, WILEY CHICHESTER, GB, vol. 31, no. 4, 30 April 1996 (1996-04-30), GB , pages 411 - 17, XP009549008, ISSN: 1076-5174
ZOLLNER, PETER ET AL.: "Structure determination of diacylglycerols as their nicotinoyl derivatives by gas chromatography-mass spectrometry", EUROPEAN MASS SPECTROMETRY, vol. 3, no. 4, 31 December 1997 (1997-12-31), pages 309 - 315, XP009520342, DOI: 10.1255/ejms.9
DEVERRE, J. R . ET AL.: "Synthesis and aqueous organization of 1,3-dipalmitoyl-2-(4-aminobutyryl) glycerol hydrochloride: a diglyceride prodrug", CHEMISTRY AND PHYSICS OF LIPIDS, vol. 59, no. 1, 31 December 1991 (1991-12-31), pages 75 - 81, XP023389940, DOI: 10.1016/0009-3084(91)90065-J
DEVERRE, JEAN ROBERT ET AL.: "In vitro and in vivo evaluation of macrofilaricidal activity of GABA and 1,3-dipalmitoyl-2-(4-aminobutyryl)glycerol hydrochloride: a diglyceride prodrug", PHARMACEUTICA ACTA HELVETIAE, vol. 67, no. 12, 31 December 1992 (1992-12-31), pages 349 - 52, XP008069879
HUBER, W. FREDERICK: "Mono-a-aminoacyl and mono-a-dipeptide triglycerides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 31 December 1955 (1955-12-31), pages 112 - 16, XP002008829, DOI: 10.1021/ja01606a036
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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