LIPID MODULATORS

WIPO Patent Application WO/2003/035602

A1

Compounds represented by the following general formula (I) and which have a PPAR&gammad modulator activity: (I) wherein A represents optionally substituted aryl&semi B represents optionally substituted aryl, optionally substituted cycloalkyl or an optionally substituted heterocyclic group&semi R^a represents H or alkyl&semi X represents a bond, O, S, CH₂, CO, NH, SO₂NH, NHSO₂, CONH, NHCO or OCH₂&semi and n is 0 or 1. Because of having effects of inhibiting the acceleration of adipocyte differentiation, controlling lipids and promoting the formation and differentiation of osteoblasts, these compounds are useful as remedies or preventives (lipid modulators) for diseases based on lipid metabolic errors and remedies or preventives for osteoporosis, diabetes and so on.

AMEMIYA YOSHIYA (JP)
WAKABAYASHI KENJI (JP)
TAKAISHI SACHIKO (JP)
KITAYAMA KEN (JP)

PCT/JP2002/011068

May 01, 2003

October 24, 2002

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SANKYO CO (JP)
AMEMIYA YOSHIYA (JP)
WAKABAYASHI KENJI (JP)
TAKAISHI SACHIKO (JP)
KITAYAMA KEN (JP)

A61K31/167; A61K31/18; A61K31/27; A61K31/353; A61K31/381; A61K31/4184; A61K31/42; A61K31/426; A61K31/44; A61K31/4418; A61K31/47; A61K31/472; A61K31/495; A61K31/505; A61K31/5375; C07C233/65; C07D207/14; C07D207/325; C07D209/48; C07D213/40; C07D213/75; C07D213/76; C07D213/81; C07D213/82; C07D215/38; C07D215/40; C07D217/22; C07D231/38; C07D231/40; C07D231/42; C07D231/56; C07D235/30; C07D237/20; C07D239/42; C07D239/46; C07D239/52; C07D241/20; C07D241/26; C07D243/10; C07D261/14; C07D261/16; C07D263/28; C07D263/58; C07D277/40; C07D277/46; C07D277/52; C07D277/66; C07D277/82; C07D285/135; C07D285/14; C07D295/26; C07D311/24; C07D333/38; C07D333/68; C07D417/04; C07D471/04; C07D521/00; C07D207/32; C07D285/12; (IPC1-7): C07C233/65; A61K31/167; A61K31/18; A61K31/27; A61K31/353; A61K31/381; A61K31/4184; A61K31/42; A61K31/426; A61K31/44; A61K31/4418; A61K31/47; A61K31/472; A61K31/495; A61K31/496; A61K31/505; A61K31/5375; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P19/00; A61P19/02; A61P19/10; A61P25/28; A61P35/00; A61P35/02; A61P43/00; C07C233/66; C07C233/67; C07C233/75; C07C233/76; C07C233/80; C07C233/81; C07C311/21; C07C311/46; C07C311/58; C07C311/64; C07C317/42; C07C323/42; C07C323/43; C07C335/20; C07C335/26; C07C335/28; C07D213/40; C07D213/75; C07D215/40; C07D217/22; C07D231/38; C07D231/56; C07D235/30; C07D237/20; C07D239/42; C07D241/06; C07D241/20; C07D261/14; C07D277/46; C07D277/66; C07D285/135; C07D285/14; C07D295/12; C07D295/192; C07D295/205; C07D295/26; C07D295/28; C07D311/54; C07D333/40; C07D333/66; C07D417/04; C07D471/04

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Ohno, Akio c/o SANKYO COMPANY (LIMITED 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, JP)

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