Title:
LIPOPOLYSACCHARIDES (LPS) EXTRACTED FROM ESCHERICHIA COLI
Document Type and Number:
WIPO Patent Application WO2001070756
Kind Code:
A3
Abstract:
The invention relates to lipopolysaccharides extracted from E. coli DSM 6601. This LPS differs from the known LPS extracted from E. coli in particular with regard to the phosphorylated sugar moiety of the core and to the degree of polymerization of the O-chain. The A lipoid corresponds structurally and biologically to the classic type of E. coli. The inventive LPS is not only suitable for identifying the coli strain which carries it, but also provides the latter with a reduced pathogenic capability, whilst retaining its immunomodulative effect.
Inventors:
PROPPERT HANS (DE)
MALINKA JUERGEN (DE)
SCHULZE JUERGEN (DE)
SONNENBORN ULRICH (DE)
ZAEHRINGER ULRICH (DE)
ULMER ARTUR (DE)
RIETSCHEL ERNST THEODOR (DE)
MALINKA JUERGEN (DE)
SCHULZE JUERGEN (DE)
SONNENBORN ULRICH (DE)
ZAEHRINGER ULRICH (DE)
ULMER ARTUR (DE)
RIETSCHEL ERNST THEODOR (DE)
Application Number:
PCT/EP2001/003153
Publication Date:
May 02, 2002
Filing Date:
March 20, 2001
Export Citation:
Assignee:
PHARMA ZENTRALE GMBH (DE)
PROPPERT HANS (DE)
MALINKA JUERGEN (DE)
SCHULZE JUERGEN (DE)
SONNENBORN ULRICH (DE)
ZAEHRINGER ULRICH (DE)
ULMER ARTUR (DE)
RIETSCHEL ERNST THEODOR (DE)
PROPPERT HANS (DE)
MALINKA JUERGEN (DE)
SCHULZE JUERGEN (DE)
SONNENBORN ULRICH (DE)
ZAEHRINGER ULRICH (DE)
ULMER ARTUR (DE)
RIETSCHEL ERNST THEODOR (DE)
International Classes:
A61K31/715; A61P35/00; C12P19/26; C08B37/00; C12P19/04; E21D20/00; C12R1/19; (IPC1-7): C12P19/04; A61K39/02
Foreign References:
| DE19844191A1 | 2000-03-30 |
Other References:
P.-E. JANSSON ET AL.: "Structural studies of the Escherichia coli O-antigen 6", CARBOHYDRATE RESEARCH, vol. 131, 1984, pages 277 - 283, XP002174749
J.A. YETHON ET AL.: "Involvement of waaY, waaQ, and waaP in the modification of Escherichia coli lipopolysaccharide and their role in the formation of a stable outer membrane", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 41, 1998, pages 26310 - 26316, XP002118875
J.A. YETHON ET AL.: "Involvement of waaY, waaQ, and waaP in the modification of Escherichia coli lipopolysaccharide and their role in the formation of a stable outer membrane", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 41, 1998, pages 26310 - 26316, XP002118875
Download PDF: