THIOKETALS AND THIOETHERS FOR INHIBITING THE EXPRESSION OF VCAM-1

WIPO Patent Application WO2001070757

A3

Thioketals and thioethers are provided that inhibit the expression of VCAM-1, and which can be used in the treatment of VCAM-1 mediated diseases including inflammatory disorders, cardiovascular diseases, occular diseases, autoimmune diseases, neurological disorders, and cancer. The compounds also can be used to treat hyperlipidemia and/or hypercholesterolemia.

MENG CHARLES Q (US)
HOONG LEE K (US)
SOMERS PATRICIA K (US)

PCT/US2001/009049

March 14, 2002

March 21, 2001

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ATHEROGENICS INC (US)
MENG CHARLES Q (US)
HOONG LEE K (US)
SOMERS PATRICIA K (US)

C07D295/08; A61K31/10; A61K31/145; A61K31/166; A61K31/185; A61K31/192; A61K31/198; A61K31/401; A61K31/4164; A61K31/4402; A61K31/4406; A61K31/505; A61K31/5375; A61K31/662; A61K31/7034; A61K45/00; A61P1/00; A61P1/02; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P11/02; A61P11/06; A61P11/08; A61P13/02; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P17/14; A61P19/02; A61P25/00; A61P25/02; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07C323/20; C07C323/60; C07D207/16; C07D213/30; C07D233/64; C07D239/26; C07H15/203; (IPC1-7): C07C323/20; A61K31/70; A61P3/06; A61P29/00; C07C323/60; C07H15/203

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WO1998051289A2	1998-11-19
WO2000028332A1	2000-05-18

EP0418648A1	1991-03-27
US5512595A	1996-04-30

DE MEGLIO, P. ET AL: "New derivatives of clofibrate and probucol. Preliminary studies on hypolipemic activity", FARMACO, ED. SCI. (1985), 40(11), 833-44, XP001015770

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