Title:
LIQUID CRYSTAL NANOPARTICLES, PREPARATION METHOD THEREFOR, DRUG DELIVERY SYSTEM CONTAINING LIPOPHILIC DRUG-INCORPORATED LIQUID CRYSTAL NANOPARTICLES
Document Type and Number:
WIPO Patent Application WO/2016/195338
Kind Code:
A3
Abstract:
The present invention relates to liquid crystal nanoparticles improving the pharmacodynamic characteristics of a lipophilic drug, a preparation method therefor, and a drug delivery system containing the same. According to the present invention, the liquid crystal nanoparticles have excellent long-term storagability, physical properties and shape stability, pharmacodynamic characteristics, such as drug extended release and a high blood plasma concentration, are remarkably improved during the delivery of a lipophilic drug, and a lipophilic drug can be selectively delivered only to the liver, and thus the liquid crystal nanoparticles can be used as an effective drug delivery system. In addition, preparation can be readily carried out with low energy and at low cost, and thus the production cost of the liquid crystal nanoparticles can be lowered and productivity can be improved.
Inventors:
KIM BYEONG MOON (KR)
LEE DONG RYEOL (KR)
PARK JI SU (KR)
BAE II HAK (KR)
LEE DONG RYEOL (KR)
PARK JI SU (KR)
BAE II HAK (KR)
Application Number:
PCT/KR2016/005666
Publication Date:
January 26, 2017
Filing Date:
May 27, 2016
Export Citation:
Assignee:
UNIV SEOUL NAT R & DB FOUND (KR)
International Classes:
A61K47/06; A61K47/08; A61K47/10; C09K19/06
Domestic Patent References:
| WO1998047487A1 | 1998-10-29 | |||
| WO2015004045A1 | 2015-01-15 |
Foreign References:
| KR20140142511A | 2014-12-12 |
Other References:
MAKAI, M. ET AL.: "Structure and Drug Release of Lamellar Liquid Crystals Containing Glycerol", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 256, no. 1-2, 2003, pages 95 - 107, XP055348537
LEE, D. R. ET AL.: "Liquid Crystal Nanoparticle Formulation as an Oral Drug Delivery System for Liver-Specific Distribution", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 11, 3 March 2016 (2016-03-03), pages 853 - 871, XP055348540
LEE, D. R. ET AL.: "Studies on Pharmacokinetics and Physicochemical Properties of an Economic Liquid Crystal Nanoparticle Formulation", THE 117TH GENERAL MEETING OF THE KOREAN CHEMICAL SOCIETY, April 2016 (2016-04-01)
LEE, D. R. ET AL.: "Liquid Crystal Nanoparticle Formulation as an Oral Drug Delivery System for Liver-Specific Distribution", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 11, 3 March 2016 (2016-03-03), pages 853 - 871, XP055348540
LEE, D. R. ET AL.: "Studies on Pharmacokinetics and Physicochemical Properties of an Economic Liquid Crystal Nanoparticle Formulation", THE 117TH GENERAL MEETING OF THE KOREAN CHEMICAL SOCIETY, April 2016 (2016-04-01)
Attorney, Agent or Firm:
LEE, Won-Hee (KR)
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