Title:
LONG LASTING NATRIURETIC PEPTIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2004011498
Kind Code:
A3
Abstract:
This invention relates to long lasting natriuretic peptide (NP) derivatives. The NP derivative has a NP peptide and a reactive entity coupled to the NP peptide. The reactive entity is able to covalently bond with a functionality on a blood component. In particular, this invention relates to NP derivatives having an extended in vivo half-life, and method for the treatment of cardio-vascular diseases and disorders such as acute decompensated congestive heart failure (CHF) and chronic CHF.
Inventors:
BRIDON DOMINIQUE P (CA)
BAKIS PETER (CA)
CARETTE JULIE (CA)
LECLAIRE FRANCE (CA)
LEGER ROGER (CA)
ROBITAILLE MARTIN (CA)
BAKIS PETER (CA)
CARETTE JULIE (CA)
LECLAIRE FRANCE (CA)
LEGER ROGER (CA)
ROBITAILLE MARTIN (CA)
Application Number:
PCT/CA2003/001097
Publication Date:
June 24, 2004
Filing Date:
July 29, 2003
Export Citation:
Assignee:
CONJUCHEM INC (CA)
BRIDON DOMINIQUE P (CA)
BAKIS PETER (CA)
CARETTE JULIE (CA)
LECLAIRE FRANCE (CA)
LEGER ROGER (CA)
ROBITAILLE MARTIN (CA)
BRIDON DOMINIQUE P (CA)
BAKIS PETER (CA)
CARETTE JULIE (CA)
LECLAIRE FRANCE (CA)
LEGER ROGER (CA)
ROBITAILLE MARTIN (CA)
International Classes:
C07K14/58; A61K38/00; (IPC1-7): C07K14/58; A61K38/22
Domestic Patent References:
| WO2000069900A2 | 2000-11-23 |
Other References:
LEGER ROGER ET AL: "Synthesis and in vitro analysis of atrial natriuretic peptide-albumin conjugates.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 20, 20 October 2003 (2003-10-20), pages 3571 - 3575, XP001156881, ISSN: 0960-894X
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